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Researchers Reveal that RNA Modification Influences Thousands of Genes

May 17, 2012: "Researchers Reveal that RNA Modification Influences Thousands of Genes." Dr. Samie Jaffrey, Dr. Kate Meyer, and their colleagues report in the May 17, 2012 issue of CELL that messenger RNA (mRNA), long thought to be a simple blueprint for protein production, is often chemically modified by addition of a methyl group to one of its bases, adenine. "This finding rewrites fundamental concepts of the composition of mRNA because, for 50 years, no one thought mRNA contained internal modifications that control function," says the study's senior investigator, Dr. Samie R. Jaffrey, an associate professor of pharmacology at Weill Cornell Medical College. Read more

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