The Center for Genomic Information Encoded by RNA Nucleotide Modifications is one of 12 NIH Centers of Excellence in Genomic Science (CEGS), which supports multi-investigator and interdisciplinary teams to develop innovative approaches and technologies to expand our understanding of the information encoded in the human genome. The Center for Genomic Information Encoded by RNA Nucleotide Modifications is based at Weill Cornell Medicine and led by Dr. Samie Jaffrey, and includes investigators at Duke, UCSF, New York Institute of Technology and St. Jude Medical Center. The $12.2M NIH-funded Center will reveal how dynamic chemical modifications in mRNA, tRNA, and ribosomal RNA control patterns of gene expression in normal physiology and disease.