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Pharmacology
postdocs in pharm

Selected Recent Publications by Our Postdoctoral Fellows

Similar articles

(updated 04/2020)

2020

2019

2018

  • Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhaes A, Ferreira JA, Osorio H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID:29459780.
  • Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. PMID:30341316.

2017

2016

  • Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, van den Brink M, Toth M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nat Commun. 2016 May 13;7:11492. doi: 10.1038/ncomms11492. PMID: 27173585
  • Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mazala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Canto C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139. PMID: 27798264

2015

2014

2013

2012

2010

  • Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic {gamma}-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010 Nov 29. [Epub ahead of print] PMCID: PMC3003001
  • Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010;67(5):769-80. PMCID: PMC2947312
  • Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010Sep;22(9):1300-7. PMID: 20406683
  • Kolesnick R, van den Brink M, Heller G, Rotolo JA. (2010) Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Jan 14;115(2):436. PMID: 20075176.
  • Luo W, Sun W, Taldone T, Rodina A, Chiosis G. (2010) Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener. 2010 Jun 3;5(1):24. PMID: 20525284
  • Lee MY, Lu A, Gudas LJ. (2010) Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. J Cell Physiol. 2010 Jul;224(1):17-27.PMID: 20232320
  • Trzupek JD, Lee D, Crowley BM, Marathias VM, Danishefsky SJ. (2010) Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet-Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan. J Am Chem Soc. 2010 Jun 23;132(24):8506-12. PMID: 20509657
  • Jeske S, Tagawa ST, Olowokure O, Selzer J, Giannakakou P, Nanus DM. (2010) Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer. Urol Oncol. 2010 May 5. [Epub ahead of print] PMID: 20451413
  • Tresguerres M, Levin LR, Buck J, Grosell M. (2010) Modulation of NaCl absorption by [HCO3-] in the marine teleost intestine is mediated by soluble adenylyl cyclase. Am J Physiol Regul Integr Comp Physiol. 2010 Apr 21. [Epub ahead of print] PMID: 20410468
  • Chanel-Vos C, Giannakakou P. (2010) CENP-E checks in microtubule-drug resistance. Cell Cycle. 2010 Apr 15;9(8). PMID: 20421712
  • Lee D, Danishefsky SJ. (2010) Cascade resulting in the reductive ethynylation of aldehydes: dissection of its components. J Am Chem Soc. 2010 Mar 31;132(12):4427-30. PMID: 20201522
  • Lee JH, Kim WH, Danishefsky SJ. (2010) An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position. Tetrahedron Lett. 2010 Mar 3;51(9):1252. PMID: 20174450
  • Wu X, Stockdill JL, Wang P, Danishefsky SJ. (2010) Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. J Am Chem Soc. 2010 Mar 31;132(12):4098-100. PMID: 20199071
  • Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS. (2010) Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90. J Org Chem. 2010 May 7;75(9):2820-35. PMID: 20392070
  • David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM. (2010) Phase I trial of ATRA-IV and depakote in patients with advanced solid tumor malignancies. Cancer Biol Ther. 2010 May 8;9(9). PMID: 20200483
  • Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ. (2010) The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regen Med. 2010 Mar;5(2):201-20.PMID: 20210581
  • Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF. (2010) Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3351-5. .PMID: 19966310
  • Perl NR, Ide ND, Prajapati S, Perfect HH, Durón SG, Gin DY. (2010) Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine. J Am Chem Soc. 2010 Feb 17;132(6):1802-3. PMID: 20095555
  • Holland JP, Caldas-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS. (2010) Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. PLoS One. 2010 Jan 25;5(1):e8859.PMID: 20111600
  • Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. (2010) Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. PMID: 20018667

 

2009 

  • Oh J.E. Zupan B., Gross S., Toth M. (2009) Paradoxical anxiogenic response of juvenile mice to fluoxetine. Neuropsychopharmacology Sep;34(10):2197-207. PMID 19440190
  • Kan C, Danishefsky SJ. (2009) Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron. 2009 Nov 7;65(45):9047-9065.PMID: 20161377
  • Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. (2009) regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog. OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs. Stem Cells Dev 2009 Sep;18(7):1093-108. PMID: 19480567
  • Zhang T., Berrocal J.G., Frizzell K.M., Gamble M.J., Dumond M.E., Krishnakumar R., Yang T., Sauve A.A., Kraus W.L. (2009) Enzymes in the NAD+ salvage pathway regulate SIRT-1 activity at target gene promoters. J Biol Chem Jul 24;284(30):20408-17. PMID: 19478080
  • Tang X.H., Su D., Albert M., Scognamiglio T., Gudas L.J. (2009) Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther Jul6;8(13)
  • Breinig M, Caldas-Lopes E, Goeppert B, Malz M, Rieker R, Bergmann F, Schirmacher P, Mayer M, Chiosis G, Kern MA. (2009) Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma. Hepatology. 2009 Jul;50(1):102-12. PMID: 19441108
  • Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. (2009) A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nat Med. 2009 Dec;15(12):1369-76. Epub 2009 Nov 22. PMID: 19966776
  • Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. . PMID: 19766101
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. (2009) Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22;114(17):3693-706. .PMID: 19666872
  • Taldone T, Chiosis G. (2009) Purine-scaffold Hsp90 inhibitors. Curr Top Med Chem. 2009;9(15):1436-46. Review. PMID: 19860732
  • Tang XH, Albert M, Scognamiglio T, Gudas LJ. (2009) A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1100-10. PMID: 19952362
  • Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem. 2009;24(3-4):219-30. PMID: 19710537
  • Liu L, Tang XH, Scognamiglio T, Gudas LJ. (2009) Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice. J Nutr Biochem. 2009 Nov 30. [Epub ahead of print] PMID: 19954945
  • Xu G, Shin SB, Jaffrey SR. (2009) Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19310-5. PMID: 19892738
  • Herold KF, Nau C, Ouyang W, Hemmings HC Jr. (2009) Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Sep;111(3):591-9 .PMID: 19672182
  • Hengst U, Deglincerti A, Kim HJ, Jeon NL, Jaffrey SR. (2009) Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nat Cell Biol. 2009 Aug;11(8):1024-30. PMID: 19620967
  • Caldas-Lopez E., Cerchietti L, Ahn J.H., Clement C.C., Robles A.I., Rodina A., Moulick K., Taldone T., Gozman A., Guo Y., Wu N., de Stanchina E., White J., Gross S.S. Ma Y., Varticovski L., Melnick A., Chiosis G. (2009) Hsp90 inhibitor PU-H71 a multimodal inhibitor og malignancy, includes complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A May 19;106(20):8366-73. PMID 19416831
  • Zhou J., Vos C.C., Gjyrezi A., Yoshida M., Khuri F.R., Tamonoi F., Giannakakou P. (2009) The protein farnesyltrasferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem Apr 10;284(15):9648-55. PMID 19228685
  • Garraway S.M., Xu Q., Inturrisi C.E. (2009) siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats. J Pain Apr;10(4):380-90. PMID 19185544
  • Hao G., Wang D., Gu J., Chen Q., Gross S.S., Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spoctrometric identification of protein citrullination. J Am Soc Mass Spectrom Apr;20(4):723-7. PMID 19200748
  • Ouyang W, Herold KF, Hemmings HC Jr. (2009) Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology. 2009 Mar;110(3):582-90.PMID: 19225394
  • Tao H., Kang Y., Taldone T., Chiosis G.(2009) Microwave-assisted one step synthesis of 8-arylmethyl-9H-puring-6-amines. Bioorg Med Chem Lett. Jan 15;19(2):415-17. PMID 19058963.
  • Rotolo J.A., Kolesnick R., Fuks Z. (2009) Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys Jan1;73(1):6-8. PMID 19100919

2008

  • Farrell J., Ramos L.S., Tresguerres M., Kamentsky M., Levin L.R., Buck J. Somatic "soluble" adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex "knockout" mice. PLoS ONE Sep22;3(9):e3251.
  • Ramos L.S., Zippin J.H., Kamenetsky M., Buck J., Levin L.R. (2008) Glucose and GLP-1 Stimulate cAMP production via distinct adenylyl cyclase in INS-1E insulinoma cells. J Gen Physiol Sep;132(3):329-38. PMID 18695009
  • Gomez-Nunez M., Haro K.J., Dao T., Chau D., Won A., Escobar-Alvarez S., Zakhaleva V., Korontsvit T., Gin D.Y., Scheinberg D.A. (2008) Non- Natural and photo-reactive amino acids as biochemical probes of immune function. PLoS ONE 3(12):e3938. PMID 19079589
  • Bultman M.S., Ma J., Gin D.Y. (2008) Synthetic access to the chlorocyclopentane cores of the proposed original and revised structures of palau'amine. Angew Chem Int Ed Engl 47(36):6821-4. PMID 18655078
  • Maslak PG, Dao T, Gomez M, Chanel S, Packin J, Korontsvit T, Zakhaleva V, Pinilla-Ibarz J, Berman E, Scheinberg DA. A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease. Leukemia Aug;22(8):1613-6. PMID: 18256684
  • Mun J., Wang Y., Voll R.J., Escuin-Borras D., Giannakakou P., Goodman M.M. (2008) Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol and radiosynthesis of 2-[(18)F]fluorothoxyestradiol for positron emission tomography. Nucl Med Biol Jul;35(5):615-22. PMID 18589306
  • Kano S., Tyler E., Salazar-Rodriguez M., Estephan R., Mackins C.J., Veerappan A., reid A.C., Silver R.B., Levi R. (2008) Immediate hypersensitivity elicits renin release from cardiac mast cells. Intl Arch Allergy Immunol; 146:71-75. PMID 18087164
  • Veerappan A., Reid A., Estephan R., O'Connor N., Thadani-Mulero M., Salazar-Rodriguez M., Levi R., Silver R.B. (2008) Mast cell renin and a local renin-angiotensin system in the airway: Role of bronchoconstriction. Proc Natl Acad Sci USA 105;1315-1320. PMID 18202178
  • Morrey C., Estephan R, Abbott GW, Levi R. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther 2008 Sep;326(3);871-8. PMID: 18523159
  • Cox LJ, Hengst U, Gurskaya NG, Lukyanov KA, Jaffrey SR. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol. 2008 Feb;10(2):149-59. Epub 2008 Jan 13. PMID: 18193038
  • Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. PMID: 18191336
  • Cheng HT, Suzuki M, Hegarty DM, Xu Q, Weyerbacher AR, South SM, Ohata M, Inturrisi CE. Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn. Neuroscience. Aug 6;155(3):948-58. PMID: 18621103
  • Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem Biol. 2008 Jan;15(1):51-61. PMID: 18158259
  • Kang Y., Taldone T., Clement C.C., Fewell S.W., Aquirre J., Brodsky J.L., Chiosis G. (2008) Design of a fluorescene polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. Jul 1;18(13):3749-51. PMID 18515098
  • Liu L, Tang XH, Gudas LJ. Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet. Biochem Pharmacol. 2008 Jun 15;75(12):2316-24. PMID: 18455147
  • Tang XH, Vivero M, Gudas LJ. Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid. Exp Cell Res. 2008 Jan 1;314(1):38-51. PMID: 17727842
  • Deng X., Yin X., Allan R., Lu D.D., Maurer C.W., Haimovitz-Friedman A., Fuks A., Shaham S., Kolesnick R. (2008) Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science Oct 3;322(5898):110-5. PMID 18832646
  • Zhuang Y, Gudas LJ. Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression. Differentiation. Sep;76(7):760-71. PMID: 18177425
  • Zhang J., Zafrullan M., Yang X, Yin X, Zhang Z., Fuks Z., Kolesnick R. (2008) Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther Sep;7(9):1490-5. PMID 18719367
  • Lane M.A., Xu J., Wilen E.W., Sylvester R., Derguini F., Gudas L.J. LIF removal increases CRABPII transcripts in embryonicstam cells cultured in retinol or 4-oxoretinol. Mol Cell Endocrinol 2008 Jan 2:280(1-2):63-74.
  • Martinez-Ceballos E., Gudas L.J. Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons. J Neurosci Res 2008 Oct;86 (13):2809-19.
  • Cai K., Gudas L.J. Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acytranferase gene. Int J Biochem Biol 2009 Mar;41(3):546:53
  • Tavares T.S., Nanus D., Yang X.J., Gudas L.J. Gene macroarray analysis of human renal cell carcinoma: the effects of HDAC inhibition andretinoid treatment. Cancer Biol Ther 2008 Oct;7(10);1607-18.
  • Krishnakumar R., Gamble M.J., Frizzell K.M., Berrocal J.G., Kininis M., Kraus W.L. (2008)Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science Feb 8;319(5864):819-21. PMID 18258916
  • Brennan E.P., Tang X.H., Stewart-Akers A.M., Gudas L.J., Badylak S.F. Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells. J Tissue Eng Regen med 2008 Dec;2(8):491-8.

2007

  • Angeles AR, Dorn DC, Kou CA, Moore MA, Danishefsky SJ. Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angew Chem Int Ed Engl. 2007;46(9):1451-4. PMID: 17387656
  • Upmacis R.K., Crabtree M.J., Deeb R.S., Shen H., Lane P.B., Benguigui L.E., Maeda N., Hajjar D.P., Gross S.S. (2007) Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol Nov;293(5):H2878-87. PMID 17766468
  • McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007 Jul;48(7):1180-9. PMID: 17607040
  • Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen. 2007 Jun;12(4):521-35. Epub 2007 Apr 13. PMID: 17435169
  • Beltrán C, Vacquier VD, Moy G, Chen Y, Buck J, Levin LR, Darszon A. Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1128-35. PMID: 17524362
  • Wacker D.A., Ruhl D.D., Balagamwala E.H., Hope K.M., Zhang T., Kraus W.L. (2007) The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transportation. Mol Cell Biol Nov;27(21):7475-85. PMID 17785446
  • Kininis M., Chen B.S., Diehl A.G., Isaacs G.D., Zhang T., Siepel A.C., Clark A.G., Kraus W.L. (2007) Genomic analyses of transcription factor binding histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol Jul;27(14):5090-104. PMID 17515612
  • McDevitt MR, Chattopadhyay D, Jaggi JS, Finn RD, Zanzonico PB, Villa C, Rey D, Mendenhall J, Batt CA, Njardarson JT, Scheinberg DA. PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE. 2007 Sep 19;2(9):e907.  PMID: 17878942
  • ENCODE Project Consortium, Birney E, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14;447(7146):799-816. PMID: 17571346
  • Jaggi JS, Carrasquillo JA, Seshan SV, Zanzonico P, Henke E, Nagel A, Schwartz J, Beattie B, Kappel BJ, Chattopadhyay D, Xiao J, Sgouros G, Larson SM, Scheinberg DA. Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor. J Clin Invest. 2007 Sep;117(9):2422-30. Erratum in: J Clin Invest. 2007 Nov;117(11):3593. PMID: 17717602
  • Singh Jaggi J, Henke E, Seshan SV, Kappel BJ, Chattopadhyay D, May C, McDevitt MR, Nolan D, Mittal V, Benezra R, Scheinberg DA. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PLoS ONE. 2007 Mar 7;2(3):e267. PMID: 17342201
  • Labitzke EM, Diani-Moore S, Rifkind AB. Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Arch Biochem Biophys. 2007 Dec 1;468(1):70-81. Epub 2007 Aug 25. PMID: 17959137
  • Garraway SM, Xu Q, Inturrisi CE. Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. J Pharmacol Exp Ther. 2007 Sep;322(3):982-8. Epub 2007 Jun 5. PMID: 17551091
  • Derakhshan B, Hao G, Gross SS. Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide. Cardiovasc Res. 2007 Jul 15;75(2):210-9. Epub 2007 May 3. PMID: 17524376
  • Hengst U, Jaffrey SR. Function and translational regulation of mRNA in developing axons. Semin Cell Dev Biol. 2007 Apr;18(2):209-15. Epub 2007 Feb 1. PMID: 17478114
  • Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23. PMID: 17977534
  • May RJ, Dao T, Pinilla-Ibarz J, Korontsvit T, Zakhaleva V, Zhang RH, Maslak P, Scheinberg DA. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4547-55. Erratum in: Clin Cancer Res. 2007 Sep 1;13(17):5226. PMID: 17671141
  • Morales A, Lee H, Goñi FM, Kolesnick R, Fernandez-Checa JC. Sphingolipids and cell death. Apoptosis. 2007 May;12(5):923-39. PMID: 17294080
  • Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, Isola J, Bendahl PO, Rosen N, Hibshoosh H, Ringnér M, Borg A, Parsons R. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9. Epub 2007 Apr 23. PMID: 17452630
  • Krauss IJ, Joyce JG, Finnefrock AC, Song HC, Dudkin VY, Geng X, Warren JD, Chastain M, Shiver JW, Danishefsky SJ. Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc. 2007 Sep 12;129(36):11042-4. Epub 2007 Aug 21. PMID: 17711286
  • Chen G, Wan Q, Tan Z, Kan C, Hua Z, Ranganathan K, Danishefsky SJ. Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl. 2007;46(39):7383-7. PMID: 17828726
  • Levi R, Seyedi N, Schaefer U, Estephan R, Mackins CJ, Tyler E, Silver RB. Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. Biochem Pharmacol. 2007 Apr 15;73(8):1146-56. Epub 2007 Jan 7. PMID: 17266940
  • Robzyk K, Oen H, Buchanan G, Butler LM, Tilley WD, Mandal AK, Rosen N, Caplan AJ. Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor. Mol Cell Endocrinol. 2007 Mar 30;268(1-2):67-74. Epub 2007 Feb 6. PMID: 17336451
  • Tsukano C, Siegel DR, Danishefsky SJ. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angew Chem Int Ed Engl. 2007;46(46):8840-4. PMID: 17935090
  • Scroggins BT, Robzyk K, Wang D, Marcu MG, Tsutsumi S, Beebe K, Cotter RJ, Felts S, Toft D, Karnitz L, Rosen N, Neckers L. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell. 2007 Jan 12;25(1):151-9. PMID: 17218278
  • Wan Q, Danishefsky SJ. Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew Chem Int Ed Engl. 2007;46(48):9248-52. PMID: 18046687
  • Owen HR, Elser M, Cheung E, Gersbach M, Kraus WL, Hottiger MO. MYBBP1a is a novel repressor of NF-kappaB. J Mol Biol. 2007 Feb 23;366(3):725-36. Epub 2006 Dec 15. PMID: 17196614
  • Cho J, Won K, Wu D, Soong Y, Liu S, Szeto HH, Hong MK. Potent mitochondria-targeted peptides reduce myocardial infarction in rats. Coron Artery Dis. 2007 May;18(3):215-20. PMID: 17429296
  • Shang S, Iwadare H, Macks DE, Ambrosini LM, Tan DS. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Org Lett. 2007 May 10;9(10):1895-8. Epub 2007 Apr 17. PMID: 17439132
  • Tang XH, Suh MJ, Li R, Gudas LJ. Cell proliferation inhibition and alterations in retinol esterification induced by phytanic acid and docosahexaenoic acid. J Lipid Res. 2007 Jan;48(1):165-76. Epub 2006 Oct 26. PMID: 17068359
  • Krauss IJ, Mandal M, Danishefsky SJ. Total synthesis of (+)-isomigrastatin. Angew Chem Int Ed Engl. 2007;46(29):5576-9. PMID: 17583888
  • Boorjian SA, Milowsky MI, Kaplan J, Albert M, Cobham MV, Coll DM, Mongan NP, Shelton G, Petrylak D, Gudas LJ, Nanus DM. Phase 1/2 clinical trial of interferon alpha2b and weekly liposome-encapsulated all-trans retinoic acid in patients with advanced renal cell carcinoma. J Immunother. 2007 Sep;30(6):655-62. PMID: 17667529
  • Thomas DA, Stauffer C, Zhao K, Yang H, Sharma VK, Szeto HH, Suthanthiran M. Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function. J Am Soc Nephrol. 2007 Jan;18(1):213-22. Epub 2006 Dec 6. PMID: 17151329
  • Mongan NP, Gudas LJ. Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation. 2007 Nov;75(9):853-70. Epub 2007 Jul 18. PMID: 17634071
  • Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. J Biol Chem. 2007 Aug 10;282(32):23639-44. Epub 2007 Jun 7. PMID: 17556361

2006

  • Antczak C, Jaggi JS, LeFave CV, Curcio MJ, McDevitt MR, Scheinberg DA. Influence of the linker on the biodistribution and catabolism of actinium-225 self-immolative tumor-targeted isotope generators. Bioconjug Chem. 2006 Nov-Dec;17(6):1551-60. PMID: 17105236
  • Chen J, Chen G, Wu B, Wan Q, Tan Z, Hua Z, Danishefsky SJ. Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Lett. 2006 Nov 13;47(46):8013-8016. PMID: 17426819
  • Gomez-Nunez M, Pinilla-Ibarz J, Dao T, May RJ, Pao M, Jaggi JS, Scheinberg DA. Peptide binding motif predictive algorithms correspond with experimental binding of leukemia vaccine candidate peptides to HLA-A*0201 molecules. Leuk Res. 2006 Oct;30(10):1293-8. Epub 2006 Mar 14. PMID: 16533527
  • Hao G, Gross SS. Electrospray tandem mass spectrometry analysis of S- and N-nitrosopeptides: facile loss of NO and radical-induced fragmentation. J Am Soc Mass Spectrom. 2006 Dec;17(12):1725-30. Epub 2006 Sep 6. PMID: 16952458
  • Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PMID: 16597739
  • Deeb RS, Hao G, Gross SS, Lainé M, Qiu JH, Resnick B, Barbar EJ, Hajjar DP, Upmacis RK. Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. J Lipid Res. 2006 May;47(5):898-911. Epub 2006 Feb 9. PMID: 16470026
  • Hao G, Derakhshan B, Shi L, Campagne F, Gross SS. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1012-7. Epub 2006 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242. PMID: 16418269
  • Mackins CJ, Kano S, Seyedi N, Schäfer U, Reid AC, Machida T, Silver RB, Levi R. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest. 2006 Apr;116(4):1063-70. PMID: 16585966
  • Pinilla-Ibarz J, May RJ, Korontsvit T, Gomez M, Kappel B, Zakhaleva V, Zhang RH, Scheinberg DA. Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein. Leukemia. 2006 Nov;20(11):2025-33. Epub 2006 Aug 31. PMID: 16990779
  • Suh MJ, Tang XH, Gudas LJ. Structure elucidation of retinoids in biological samples using postsource decay laser desorption/ionization mass spectrometry after high-performance liquid chromatography separation. Anal Chem. 2006 Aug 15;78(16):5719-28. PMID: 16906716
  • Rosen N, She QB. AKT and cancer--is it all mTOR? Cancer Cell. 2006 Oct;10(4):254-6. PMID: 17045203
  • Liu H, Siegel DR, Danishefsky SJ. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Org Lett. 2006 Feb 2;8(3):423-5. PMID: 16435850
  • Chen G, Warren JD, Chen J, Wu B, Wan Q, Danishefsky SJ. Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. J Am Chem Soc. 2006 Jun 14;128(23):7460-2. PMID: 16756298
  • Wu B, Chen J, Warren JD, Chen G, Hua Z, Danishefsky SJ. Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angew Chem Int Ed Engl. 2006 Jun 19;45(25):4116-25. PMID: 16710874
  • Siegel DR, Danishefsky SJ. Total synthesis of garsubellin A. J Am Chem Soc. 2006 Feb 1;128(4):1048-9. PMID: 16433500
  • Wan Q, Chen J, Chen G, Danishefsky SJ. A potentially valuable advance in the synthesis of carbohydrate-based anticancer vaccines through extended cycloaddition chemistry. J Org Chem. 2006 Oct 13;71(21):8244-9. PMID: 17025318
  • Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, Spassova MK, Keding SJ, Allen J, Ouerfelli O, Wilson RM, Danishefsky SJ. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc. 2006 Mar 1;128(8):2715-25. PMID: 16492059
  • Diani-Moore S, Labitzke E, Brown R, Garvin A, Wong L, Rifkind AB. Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo. Toxicol Sci. 2006 Mar;90(1):96-110. Epub 2005 Dec 5. PMID: 16330490
  • Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):57-62. Epub 2005 Dec 21. PMID: 16371460
  • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006 Feb 1;66(3):1500-8. PMID: 16452206
  • Zhang Y, Pan YX, Kolesnikov Y, Pasternak GW. Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system. Brain Res. 2006 Jul 12;1099(1):33-43. Epub 2006 Jun 21. PMID: 16793025
  • Raman JD, Mongan NP, Liu L, Tickoo SK, Nanus DM, Scherr DS, Gudas LJ. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Carcinogenesis. 2006 Mar;27(3):499-507. Epub 2005 Dec 12. PMID: 16344273
  • Mongan NP, Martin KM, Gudas LJ. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. Mol Carcinog. 2006 Dec;45(12):887-900. PMID: 16865673
  • Carcache DA, Cho YS, Hua Z, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures. J Am Chem Soc. 2006 Jan 25;128(3):1016-22. PMID: 16417394
  • Lambert TH, Danishefsky SJ. Total synthesis of UCS1025A. J Am Chem Soc. 2006 Jan 18;128(2):426-7. PMID: 16402826
  • Deeb RS, Shen H, Gamss C, Gavrilova T, Summers BD, Kraemer R, Hao G, Gross SS, Lainé M, Maeda N, Hajjar DP, Upmacis RK. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Am J Pathol. 2006 Jan;168(1):349-62. PMID: 16400036
  • Wu KY, Zippin JH, Huron DR, Kamenetsky M, Hengst U, Buck J, Levin LR, Jaffrey SR. Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci. 2006 Oct;9(10):1257-64. Epub 2006 Sep 10. PMID: 16964251
  • Hengst U, Cox LJ, Macosko EZ, Jaffrey SR. Functional and selective RNA interference in developing axons and growth cones. J Neurosci. 2006 May 24;26(21):5727-32.  PMID: 16723529
  • Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J. 2006 Oct 4;25(19):4490-502. Epub 2006 Sep 21. PMID: 16990801
  • Diani-Moore S, Papachristou F, Labitzke E, Rifkind AB. Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab Dispos. 2006 Aug;34(8):1376-85. Epub 2006 May 19. PMID: 16714371
  • Sheren-Manoff M., Shin S.J., Su D., Bok D., Rando R.R., Gudas L.J. Reduced lecithin: retinol acytransferase expression in human breas cancer. Int J Oncol 2006 Nov;29(5);1193-9.
  • Kong K.Y., Marcus A. I., Hong J.Y., Giannakakou P., Wanf M.D. (2006) Automatic microtubule tracking for QD-based in vivo cell imaging and drug efficacy study. Conf Proc IEEE Eng Med Biol Soc 2006;1:3321-4. PMID 17947021

2005

  • Dao T, Gomez-Nunez M, Antczak C, Kappel B, Jaggi JS, Korontsvit T, Zakhaleva V, Scheinberg DA. Natural killer cells license dendritic cell cross-presentation of B lymphoma cell--associated antigens. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8763-72. PMID: 16361564
  • Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS, Levin LR, Williams CJ, Buck J, Moss SB. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59. PMID: 16054031
  • Cheung E, Acevedo ML, Cole PA, Kraus WL. Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):559-64. Epub 2005 Jan 10. PMID: 15642950
  • Wu KY, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR. Local translation of RhoA regulates growth cone collapse. Nature. 2005 Aug 18;436(7053):1020-4.  PMID: 16107849
  • He XG, Gerona-Navarro G, Jaffrey SR. Ligand discovery using small molecule microarrays. J Pharmacol Exp Ther. 2005 Apr;313(1):1-7. Epub 2004 Nov 10. PMID: 15537823
  • Mongan NP, Gudas LJ. Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells. Mol Cancer Ther. 2005 Mar;4(3):477-86. PMID: 15767557
  • Ferreras JA, Ryu JS, Di Lello F, Tan DS, Quadri LE. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol. 2005 Jun;1(1):29-32. Epub 2005 May 24. PMID: 16407990
  • Boorjian S, Scherr DS, Mongan NP, Zhuang Y, Nanus DM, Gudas LJ. Retinoid receptor mRNA expression profiles in human bladder cancer specimens. Int J Oncol. 2005 Apr;26(4):1041-8. PMID: 15754000
  • Levin E, Premkumar A, Veenman L, Kugler W, Leschiner S, Spanier I, Weisinger G, Lakomek M, Weizman A, Snyder SH, Pasternak GW, Gavish M. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Biochemistry. 2005 Jul 26;44(29):9924-35. PMID: 16026165
  • Hua Z, Carcache DA, Tian Y, Li YM, Danishefsky SJ. The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. J Org Chem. 2005 Nov 25;70(24):9849-56. PMID: 16292815
  • Mandal M, Yun H, Dudley GB, Lin S, Tan DS, Danishefsky SJ. Total synthesis of guanacastepene a: a route to enantiomeric control. J Org Chem. 2005 Dec 23;70(26):10619-37. PMID: 16355979
  • Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med. 2005 May;11(5):484-90. Epub 2005 May 1. Erratum in: Nat Med. 2006 Feb;12(2):253. PMID: 15864314
  • Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R. Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem. 2005 Jul 15;280(28):26425-34. Epub 2005 Apr 22. PMID: 15849201
  • Endo A, Danishefsky SJ. Total synthesis of salinosporamide A. J Am Chem Soc. 2005 Jun 15;127(23):8298-9. PMID: 15941259
  • Palomba ML, Roberts WK, Dao T, Manukian G, Guevara-Patiño JA, Wolchok JD, Scheinberg DA, Houghton AN. CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma. Clin Cancer Res. 2005 Jan 1;11(1):370-9. PMID: 15671568
  • Diblasi CM, Macks DE, Tan DS. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Org Lett. 2005 Apr 28;7(9):1777-80. PMID: 15844904
  • Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8570-6. PMID: 16361539
  • Seyedi N, Mackins CJ, Machida T, Reid AC, Silver RB, Levi R. Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium. J Pharmacol Exp Ther. 2005 Jan;312(1):272-80. Epub 2004 Aug 11. PMID: 15306634
  • She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell. 2005 Oct;8(4):287-97. PMID: 16226704
  • Cho YS, Wan Q, Danishefsky SJ. Organic synthesis in pursuit of immunology: large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine. Bioorg Med Chem. 2005 Sep 1;13(17):5259-66. PMID: 16006132
  • Zhao K, Luo G, Giannelli S, Szeto HH. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochem Pharmacol. 2005 Dec 5;70(12):1796-806. Epub 2005 Oct 10. PMID: 16216225
  • Szeto HH, Schiller PW, Zhao K, Luo G. Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides. FASEB J. 2005 Jan;19(1):118-20. Epub 2004 Oct 15. PMID: 15489247
  • Ouerfelli O, Warren JD, Wilson RM, Danishefsky SJ. Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Rev Vaccines. 2005 Oct;4(5):677-85. PMID: 16221069
  • Waters SP, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. J Am Chem Soc. 2005 Oct 5;127(39):13514-5. PMID: 16190712

2004

  • Reid AC, Mackins CJ, Seyedi N, Levi R, Silver RB. Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1448-54. Epub 2003 Dec 18. PMID: 14684374
  • Warren JD, Miller JS, Keding SJ, Danishefsky SJ. Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc. 2004 Jun 2;126(21):6576-8. PMID: 15161285
  • Hao G, Xie L, Gross SS. Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. J Biol Chem. 2004 Aug 27;279(35):36192-200. Epub 2004 Jun 10. PMID: 15192091
  • Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cardon-Cardo C, Nimer S, Fuks Z, Kolesnick R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res. 2004 Nov 15;64(22):8285-91. PMID: 15548696
  • Dudkin VY, Orlova M, Geng X, Mandal M, Olson WC, Danishefsky SJ. Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. J Am Chem Soc. 2004 Aug 11;126(31):9560-2. PMID: 15291558
  • Boorjian S, Ugras S, Mongan NP, Gudas LJ, You X, Tickoo SK, Scherr DS. Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology. 2004 Aug;64(2):383-8. PMID: 15302512
  • Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, Szeto HH. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem. 2004 Aug 13;279(33):34682-90. Epub 2004 Jun 2. PMID: 15178689
  • Boorjian S, Tickoo SK, Mongan NP, Yu H, Bok D, Rando RR, Nanus DM, Scherr DS, Gudas LJ. Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Clin Cancer Res. 2004 May 15;10(10):3429-37. PMID: 15161698
  • Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. Epub 2004 Nov 24. PMID: 15563588
  • Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. J Org Chem. 2004 Oct 15;69(21):7344-7. PMID: 15471490
  • Geng X, Dudkin VY, Mandal M, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. Angew Chem Int Ed Engl. 2004 May 3;43(19):2562-5. PMID: 15127453
  • Kolesnick R, Xing HR. Inflammatory bowel disease reveals the kinase activity of KSR1. J Clin Invest. 2004 Nov;114(9):1233-7. PMID: 15520853
  • Xing HR, Campodonico L, Kolesnick R. The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. J Biol Chem. 2004 Jun 18;279(25):26210-4. Epub 2004 Apr 13. PMID: 15084597
  • Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R. Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet. 2004 Aug;36(8):906-12. Epub 2004 Jul 25. PMID: 15273685
  • Mandal M, Dudkin VY, Geng X, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments. Angew Chem Int Ed Engl. 2004 May 3;43(19):2557-61. PMID: 15127452
  • Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):301-13. PMID: 14734483
  • Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem. 2004 Nov 19;279(47):48615-9. Epub 2004 Sep 29. PMID: 15456788

2003

  • Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochem Biophys Res Commun. 2003 Dec 12;312(2):309-15. PMID: 14637138
  • Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5;278(49):49523-9. Epub 2003 Sep 25. PMID: 14512417
  • McGarry RC, Barron YD, Carvalho MF, Hill JE, Gold D, Cheung E, Kraus WL, Lazarowitz SG. A novel Arabidopsis acetyltransferase interacts with the geminivirus movement protein NSP. Plant Cell. 2003 Jul;15(7):1605-18.  PMID: 12837950
  • Cheung E, Schwabish MA, Kraus WL. Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta. EMBO J. 2003 Feb 3;22(3):600-11. PMID: 12554660
  • Koyama M, Seyedi N, Fung-Leung WP, Lovenberg TW, Levi R. Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors. Mol Pharmacol. 2003 Feb;63(2):378-82. PMID: 12527809
  • Xing HR, Cordon-Cardo C, Deng X, Tong W, Campodonico L, Fuks Z, Kolesnick R. Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med. 2003 Oct;9(10):1266-8. Epub 2003 Sep 7. PMID: 12960962
  • Lozano J, Xing R, Cai Z, Jensen HL, Trempus C, Mark W, Cannon R, Kolesnick R. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 2003 Jul 15;63(14):4232-8. PMID: 12874031
  • Zhao K, Luo G, Zhao GM, Schiller PW, Szeto HH. Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide. J Pharmacol Exp Ther. 2003 Jan;304(1):425-32. PMID: 12490619
  • Sun XC, Zhai CB, Cui M, Chen Y, Levin LR, Buck J, Bonanno JA. HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol. 2003 May;284(5):C1114-22. Epub 2003 Jan 8. PMID: 12519749
  • Maj JG, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks Z. Microvascular function regulates intestinal crypt response to radiation. Cancer Res. 2003 Aug 1;63(15):4338-41. PMID: 12907601
  • Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J. Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J. 2003 Jan;17(1):82-4. Epub 2002 Nov 15. PMID: 12475901
  • Crabtree M, Hao G, Gross SS. Detection of cysteine S-nitrosylation and tyrosine 3-nitration in kidney proteins. Methods Mol Med. 2003;86:373-84. PMID: 12886782
  • Zhuang Y, Faria TN, Chambon P, Gudas LJ. Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. Mol Cancer Res. 2003 Jun;1(8):619-30. PMID: 12805409
  • Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003 May 16;300(5622):1155-9. PMID: 12750523

2002

  • Cheung E, Zarifyan AS, Kraus WL. Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation. Mol Cell Biol. 2002 Apr;22(8):2463-71. PMID: 11909941
  • Wood E, Johan Broekman M, Kirley TL, Diani-Moore S, Tickner M, Drosopoulos JH, Islam N, Park JI, Marcus AJ, Rifkind AB. Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 2002 Nov 1;407(1):49-62. PMID: 12392715
  • Levi R, Silver RB, Mackins CJ, Seyedi N, Koyama M. Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release. Int Immunopharmacol. 2002 Dec;2(13-14):1965-73. PMID: 12489810
  • Seyedi N, Koyama M, Mackins CJ, Levi R. Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. J Pharmacol Exp Ther. 2002 Aug;302(2):539-44. PMID: 12130713
  • Silver RB, Poonwasi KS, Seyedi N, Wilson SJ, Lovenberg TW, Levi R. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):501-6. Epub 2001 Dec 18. PMID: 11752397

2001

  • Xing HR, Kolesnick R. Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J Biol Chem. 2001 Mar 30;276(13):9733-41. Epub 2000 Dec 27. PMID: 11134016
  • Lane P, Hao G, Gross SS. S-nitrosylation is emerging as a specific and fundamental posttranslational protein modification: head-to-head comparison with O-phosphorylation. Sci STKE. 2001 Jun 12;2001(86):RE1. PMID: 11752656
  • Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner MO, Kolesnick RN. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J. 2001 Sep 17;20(18):5114-28. PMID: 11566876

2000

  • Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 2000 Jul 28;289(5479):625-8.  PMID: 1091562
  • Lukashok SA, Tarassishin L, Li Y, Horwitz MS. An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase. J Virol. 2000 May;74(10):4705-9. PMID: 10775608
  • Levi R, Maruyama R, Smith NC, Seyedi N. Is the lower mortality in patients treated with aspirin and angiotensin-converting enzyme inhibitors due to decreased norepinephrine release? J Am Coll Cardiol. 2000 Mar 1;35(3):817-9. PMID: 10716490
  • Xing HR, Lozano J, Kolesnick R. Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. J Biol Chem. 2000 Jun 9;275(23):17276-80. PMID: 10764733

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