Selected Recent Publications by Our Postdoctoral Fellows

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(updated 08/2023)






  • Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhaes A, Ferreira JA, Osorio H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID:29459780.
  • Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. PMID:30341316.



  • Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, van den Brink M, Toth M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nat Commun. 2016 May 13;7:11492. doi: 10.1038/ncomms11492. PMID: 27173585
  • Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mazala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Canto C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139. PMID: 27798264






  • Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic {gamma}-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010 Nov 29. [Epub ahead of print] PMCID: PMC3003001
  • Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010;67(5):769-80. PMCID: PMC2947312
  • Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010Sep;22(9):1300-7. PMID: 20406683
  • Kolesnick R, van den Brink M, Heller G, Rotolo JA. (2010) Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Jan 14;115(2):436. PMID: 20075176.
  • Luo W, Sun W, Taldone T, Rodina A, Chiosis G. (2010) Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener. 2010 Jun 3;5(1):24. PMID: 20525284
  • Lee MY, Lu A, Gudas LJ. (2010) Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. J Cell Physiol. 2010 Jul;224(1):17-27.PMID: 20232320
  • Trzupek JD, Lee D, Crowley BM, Marathias VM, Danishefsky SJ. (2010) Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet-Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan. J Am Chem Soc. 2010 Jun 23;132(24):8506-12. PMID: 20509657
  • Jeske S, Tagawa ST, Olowokure O, Selzer J, Giannakakou P, Nanus DM. (2010) Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer. Urol Oncol. 2010 May 5. [Epub ahead of print] PMID: 20451413
  • Tresguerres M, Levin LR, Buck J, Grosell M. (2010) Modulation of NaCl absorption by [HCO3-] in the marine teleost intestine is mediated by soluble adenylyl cyclase. Am J Physiol Regul Integr Comp Physiol. 2010 Apr 21. [Epub ahead of print] PMID: 20410468
  • Chanel-Vos C, Giannakakou P. (2010) CENP-E checks in microtubule-drug resistance. Cell Cycle. 2010 Apr 15;9(8). PMID: 20421712
  • Lee D, Danishefsky SJ. (2010) Cascade resulting in the reductive ethynylation of aldehydes: dissection of its components. J Am Chem Soc. 2010 Mar 31;132(12):4427-30. PMID: 20201522
  • Lee JH, Kim WH, Danishefsky SJ. (2010) An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position. Tetrahedron Lett. 2010 Mar 3;51(9):1252. PMID: 20174450
  • Wu X, Stockdill JL, Wang P, Danishefsky SJ. (2010) Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. J Am Chem Soc. 2010 Mar 31;132(12):4098-100. PMID: 20199071
  • Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS. (2010) Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90. J Org Chem. 2010 May 7;75(9):2820-35. PMID: 20392070
  • David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM. (2010) Phase I trial of ATRA-IV and depakote in patients with advanced solid tumor malignancies. Cancer Biol Ther. 2010 May 8;9(9). PMID: 20200483
  • Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ. (2010) The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regen Med. 2010 Mar;5(2):201-20.PMID: 20210581
  • Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF. (2010) Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3351-5. .PMID: 19966310
  • Perl NR, Ide ND, Prajapati S, Perfect HH, Durón SG, Gin DY. (2010) Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine. J Am Chem Soc. 2010 Feb 17;132(6):1802-3. PMID: 20095555
  • Holland JP, Caldas-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS. (2010) Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. PLoS One. 2010 Jan 25;5(1):e8859.PMID: 20111600
  • Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. (2010) Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. PMID: 20018667



  • Oh J.E. Zupan B., Gross S., Toth M. (2009) Paradoxical anxiogenic response of juvenile mice to fluoxetine. Neuropsychopharmacology Sep;34(10):2197-207. PMID 19440190
  • Kan C, Danishefsky SJ. (2009) Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron. 2009 Nov 7;65(45):9047-9065.PMID: 20161377
  • Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. (2009) regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog. OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs. Stem Cells Dev 2009 Sep;18(7):1093-108. PMID: 19480567
  • Zhang T., Berrocal J.G., Frizzell K.M., Gamble M.J., Dumond M.E., Krishnakumar R., Yang T., Sauve A.A., Kraus W.L. (2009) Enzymes in the NAD+ salvage pathway regulate SIRT-1 activity at target gene promoters. J Biol Chem Jul 24;284(30):20408-17. PMID: 19478080
  • Tang X.H., Su D., Albert M., Scognamiglio T., Gudas L.J. (2009) Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther Jul6;8(13)
  • Breinig M, Caldas-Lopes E, Goeppert B, Malz M, Rieker R, Bergmann F, Schirmacher P, Mayer M, Chiosis G, Kern MA. (2009) Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma. Hepatology. 2009 Jul;50(1):102-12. PMID: 19441108
  • Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. (2009) A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nat Med. 2009 Dec;15(12):1369-76. Epub 2009 Nov 22. PMID: 19966776
  • Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. . PMID: 19766101
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. (2009) Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22;114(17):3693-706. .PMID: 19666872
  • Taldone T, Chiosis G. (2009) Purine-scaffold Hsp90 inhibitors. Curr Top Med Chem. 2009;9(15):1436-46. Review. PMID: 19860732
  • Tang XH, Albert M, Scognamiglio T, Gudas LJ. (2009) A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1100-10. PMID: 19952362
  • Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem. 2009;24(3-4):219-30. PMID: 19710537
  • Liu L, Tang XH, Scognamiglio T, Gudas LJ. (2009) Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice. J Nutr Biochem. 2009 Nov 30. [Epub ahead of print] PMID: 19954945
  • Xu G, Shin SB, Jaffrey SR. (2009) Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19310-5. PMID: 19892738
  • Herold KF, Nau C, Ouyang W, Hemmings HC Jr. (2009) Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Sep;111(3):591-9 .PMID: 19672182
  • Hengst U, Deglincerti A, Kim HJ, Jeon NL, Jaffrey SR. (2009) Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nat Cell Biol. 2009 Aug;11(8):1024-30. PMID: 19620967
  • Caldas-Lopez E., Cerchietti L, Ahn J.H., Clement C.C., Robles A.I., Rodina A., Moulick K., Taldone T., Gozman A., Guo Y., Wu N., de Stanchina E., White J., Gross S.S. Ma Y., Varticovski L., Melnick A., Chiosis G. (2009) Hsp90 inhibitor PU-H71 a multimodal inhibitor og malignancy, includes complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A May 19;106(20):8366-73. PMID 19416831
  • Zhou J., Vos C.C., Gjyrezi A., Yoshida M., Khuri F.R., Tamonoi F., Giannakakou P. (2009) The protein farnesyltrasferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem Apr 10;284(15):9648-55. PMID 19228685
  • Garraway S.M., Xu Q., Inturrisi C.E. (2009) siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats. J Pain Apr;10(4):380-90. PMID 19185544
  • Hao G., Wang D., Gu J., Chen Q., Gross S.S., Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spoctrometric identification of protein citrullination. J Am Soc Mass Spectrom Apr;20(4):723-7. PMID 19200748
  • Ouyang W, Herold KF, Hemmings HC Jr. (2009) Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology. 2009 Mar;110(3):582-90.PMID: 19225394
  • Tao H., Kang Y., Taldone T., Chiosis G.(2009) Microwave-assisted one step synthesis of 8-arylmethyl-9H-puring-6-amines. Bioorg Med Chem Lett. Jan 15;19(2):415-17. PMID 19058963.
  • Rotolo J.A., Kolesnick R., Fuks Z. (2009) Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys Jan1;73(1):6-8. PMID 19100919


  • Farrell J., Ramos L.S., Tresguerres M., Kamentsky M., Levin L.R., Buck J. Somatic "soluble" adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex "knockout" mice. PLoS ONE Sep22;3(9):e3251.
  • Ramos L.S., Zippin J.H., Kamenetsky M., Buck J., Levin L.R. (2008) Glucose and GLP-1 Stimulate cAMP production via distinct adenylyl cyclase in INS-1E insulinoma cells. J Gen Physiol Sep;132(3):329-38. PMID 18695009
  • Gomez-Nunez M., Haro K.J., Dao T., Chau D., Won A., Escobar-Alvarez S., Zakhaleva V., Korontsvit T., Gin D.Y., Scheinberg D.A. (2008) Non- Natural and photo-reactive amino acids as biochemical probes of immune function. PLoS ONE 3(12):e3938. PMID 19079589
  • Bultman M.S., Ma J., Gin D.Y. (2008) Synthetic access to the chlorocyclopentane cores of the proposed original and revised structures of palau'amine. Angew Chem Int Ed Engl 47(36):6821-4. PMID 18655078
  • Maslak PG, Dao T, Gomez M, Chanel S, Packin J, Korontsvit T, Zakhaleva V, Pinilla-Ibarz J, Berman E, Scheinberg DA. A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease. Leukemia Aug;22(8):1613-6. PMID: 18256684
  • Mun J., Wang Y., Voll R.J., Escuin-Borras D., Giannakakou P., Goodman M.M. (2008) Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol and radiosynthesis of 2-[(18)F]fluorothoxyestradiol for positron emission tomography. Nucl Med Biol Jul;35(5):615-22. PMID 18589306
  • Kano S., Tyler E., Salazar-Rodriguez M., Estephan R., Mackins C.J., Veerappan A., reid A.C., Silver R.B., Levi R. (2008) Immediate hypersensitivity elicits renin release from cardiac mast cells. Intl Arch Allergy Immunol; 146:71-75. PMID 18087164
  • Veerappan A., Reid A., Estephan R., O'Connor N., Thadani-Mulero M., Salazar-Rodriguez M., Levi R., Silver R.B. (2008) Mast cell renin and a local renin-angiotensin system in the airway: Role of bronchoconstriction. Proc Natl Acad Sci USA 105;1315-1320. PMID 18202178
  • Morrey C., Estephan R, Abbott GW, Levi R. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther 2008 Sep;326(3);871-8. PMID: 18523159
  • Cox LJ, Hengst U, Gurskaya NG, Lukyanov KA, Jaffrey SR. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol. 2008 Feb;10(2):149-59. Epub 2008 Jan 13. PMID: 18193038
  • Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. PMID: 18191336
  • Cheng HT, Suzuki M, Hegarty DM, Xu Q, Weyerbacher AR, South SM, Ohata M, Inturrisi CE. Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn. Neuroscience. Aug 6;155(3):948-58. PMID: 18621103
  • Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem Biol. 2008 Jan;15(1):51-61. PMID: 18158259
  • Kang Y., Taldone T., Clement C.C., Fewell S.W., Aquirre J., Brodsky J.L., Chiosis G. (2008) Design of a fluorescene polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. Jul 1;18(13):3749-51. PMID 18515098
  • Liu L, Tang XH, Gudas LJ. Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet. Biochem Pharmacol. 2008 Jun 15;75(12):2316-24. PMID: 18455147
  • Tang XH, Vivero M, Gudas LJ. Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid. Exp Cell Res. 2008 Jan 1;314(1):38-51. PMID: 17727842
  • Deng X., Yin X., Allan R., Lu D.D., Maurer C.W., Haimovitz-Friedman A., Fuks A., Shaham S., Kolesnick R. (2008) Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science Oct 3;322(5898):110-5. PMID 18832646
  • Zhuang Y, Gudas LJ. Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression. Differentiation. Sep;76(7):760-71. PMID: 18177425
  • Zhang J., Zafrullan M., Yang X, Yin X, Zhang Z., Fuks Z., Kolesnick R. (2008) Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther Sep;7(9):1490-5. PMID 18719367
  • Lane M.A., Xu J., Wilen E.W., Sylvester R., Derguini F., Gudas L.J. LIF removal increases CRABPII transcripts in embryonicstam cells cultured in retinol or 4-oxoretinol. Mol Cell Endocrinol 2008 Jan 2:280(1-2):63-74.
  • Martinez-Ceballos E., Gudas L.J. Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons. J Neurosci Res 2008 Oct;86 (13):2809-19.
  • Cai K., Gudas L.J. Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acytranferase gene. Int J Biochem Biol 2009 Mar;41(3):546:53
  • Tavares T.S., Nanus D., Yang X.J., Gudas L.J. Gene macroarray analysis of human renal cell carcinoma: the effects of HDAC inhibition andretinoid treatment. Cancer Biol Ther 2008 Oct;7(10);1607-18.
  • Krishnakumar R., Gamble M.J., Frizzell K.M., Berrocal J.G., Kininis M., Kraus W.L. (2008)Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science Feb 8;319(5864):819-21. PMID 18258916
  • Brennan E.P., Tang X.H., Stewart-Akers A.M., Gudas L.J., Badylak S.F. Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells. J Tissue Eng Regen med 2008 Dec;2(8):491-8.


  • Angeles AR, Dorn DC, Kou CA, Moore MA, Danishefsky SJ. Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angew Chem Int Ed Engl. 2007;46(9):1451-4. PMID: 17387656
  • Upmacis R.K., Crabtree M.J., Deeb R.S., Shen H., Lane P.B., Benguigui L.E., Maeda N., Hajjar D.P., Gross S.S. (2007) Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol Nov;293(5):H2878-87. PMID 17766468
  • McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007 Jul;48(7):1180-9. PMID: 17607040
  • Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen. 2007 Jun;12(4):521-35. Epub 2007 Apr 13. PMID: 17435169
  • Beltrán C, Vacquier VD, Moy G, Chen Y, Buck J, Levin LR, Darszon A. Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1128-35. PMID: 17524362
  • Wacker D.A., Ruhl D.D., Balagamwala E.H., Hope K.M., Zhang T., Kraus W.L. (2007) The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transportation. Mol Cell Biol Nov;27(21):7475-85. PMID 17785446
  • Kininis M., Chen B.S., Diehl A.G., Isaacs G.D., Zhang T., Siepel A.C., Clark A.G., Kraus W.L. (2007) Genomic analyses of transcription factor binding histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol Jul;27(14):5090-104. PMID 17515612
  • McDevitt MR, Chattopadhyay D, Jaggi JS, Finn RD, Zanzonico PB, Villa C, Rey D, Mendenhall J, Batt CA, Njardarson JT, Scheinberg DA. PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE. 2007 Sep 19;2(9):e907.  PMID: 17878942
  • ENCODE Project Consortium, Birney E, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14;447(7146):799-816. PMID: 17571346
  • Jaggi JS, Carrasquillo JA, Seshan SV, Zanzonico P, Henke E, Nagel A, Schwartz J, Beattie B, Kappel BJ, Chattopadhyay D, Xiao J, Sgouros G, Larson SM, Scheinberg DA. Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor. J Clin Invest. 2007 Sep;117(9):2422-30. Erratum in: J Clin Invest. 2007 Nov;117(11):3593. PMID: 17717602
  • Singh Jaggi J, Henke E, Seshan SV, Kappel BJ, Chattopadhyay D, May C, McDevitt MR, Nolan D, Mittal V, Benezra R, Scheinberg DA. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PLoS ONE. 2007 Mar 7;2(3):e267. PMID: 17342201
  • Labitzke EM, Diani-Moore S, Rifkind AB. Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Arch Biochem Biophys. 2007 Dec 1;468(1):70-81. Epub 2007 Aug 25. PMID: 17959137
  • Garraway SM, Xu Q, Inturrisi CE. Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. J Pharmacol Exp Ther. 2007 Sep;322(3):982-8. Epub 2007 Jun 5. PMID: 17551091
  • Derakhshan B, Hao G, Gross SS. Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide. Cardiovasc Res. 2007 Jul 15;75(2):210-9. Epub 2007 May 3. PMID: 17524376
  • Hengst U, Jaffrey SR. Function and translational regulation of mRNA in developing axons. Semin Cell Dev Biol. 2007 Apr;18(2):209-15. Epub 2007 Feb 1. PMID: 17478114
  • Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23. PMID: 17977534
  • May RJ, Dao T, Pinilla-Ibarz J, Korontsvit T, Zakhaleva V, Zhang RH, Maslak P, Scheinberg DA. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4547-55. Erratum in: Clin Cancer Res. 2007 Sep 1;13(17):5226. PMID: 17671141
  • Morales A, Lee H, Goñi FM, Kolesnick R, Fernandez-Checa JC. Sphingolipids and cell death. Apoptosis. 2007 May;12(5):923-39. PMID: 17294080
  • Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, Isola J, Bendahl PO, Rosen N, Hibshoosh H, Ringnér M, Borg A, Parsons R. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9. Epub 2007 Apr 23. PMID: 17452630
  • Krauss IJ, Joyce JG, Finnefrock AC, Song HC, Dudkin VY, Geng X, Warren JD, Chastain M, Shiver JW, Danishefsky SJ. Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc. 2007 Sep 12;129(36):11042-4. Epub 2007 Aug 21. PMID: 17711286
  • Chen G, Wan Q, Tan Z, Kan C, Hua Z, Ranganathan K, Danishefsky SJ. Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl. 2007;46(39):7383-7. PMID: 17828726
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  • Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003 May 16;300(5622):1155-9. PMID: 12750523


  • Cheung E, Zarifyan AS, Kraus WL. Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation. Mol Cell Biol. 2002 Apr;22(8):2463-71. PMID: 11909941
  • Wood E, Johan Broekman M, Kirley TL, Diani-Moore S, Tickner M, Drosopoulos JH, Islam N, Park JI, Marcus AJ, Rifkind AB. Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 2002 Nov 1;407(1):49-62. PMID: 12392715
  • Levi R, Silver RB, Mackins CJ, Seyedi N, Koyama M. Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release. Int Immunopharmacol. 2002 Dec;2(13-14):1965-73. PMID: 12489810
  • Seyedi N, Koyama M, Mackins CJ, Levi R. Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. J Pharmacol Exp Ther. 2002 Aug;302(2):539-44. PMID: 12130713
  • Silver RB, Poonwasi KS, Seyedi N, Wilson SJ, Lovenberg TW, Levi R. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):501-6. Epub 2001 Dec 18. PMID: 11752397


  • Xing HR, Kolesnick R. Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J Biol Chem. 2001 Mar 30;276(13):9733-41. Epub 2000 Dec 27. PMID: 11134016
  • Lane P, Hao G, Gross SS. S-nitrosylation is emerging as a specific and fundamental posttranslational protein modification: head-to-head comparison with O-phosphorylation. Sci STKE. 2001 Jun 12;2001(86):RE1. PMID: 11752656
  • Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner MO, Kolesnick RN. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J. 2001 Sep 17;20(18):5114-28. PMID: 11566876


  • Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 2000 Jul 28;289(5479):625-8.  PMID: 1091562
  • Lukashok SA, Tarassishin L, Li Y, Horwitz MS. An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase. J Virol. 2000 May;74(10):4705-9. PMID: 10775608
  • Levi R, Maruyama R, Smith NC, Seyedi N. Is the lower mortality in patients treated with aspirin and angiotensin-converting enzyme inhibitors due to decreased norepinephrine release? J Am Coll Cardiol. 2000 Mar 1;35(3):817-9. PMID: 10716490
  • Xing HR, Lozano J, Kolesnick R. Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. J Biol Chem. 2000 Jun 9;275(23):17276-80. PMID: 10764733

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