Selected Recent Publications by Our Postdoctoral Fellows

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(updated 12/2023)

2023

• Zallar LJ, Rivera-Irizarry JK, Hamor PU, Pigulevskiy I, Liu D, Welday JP, Rico Rozo AS, Bender R, Asfouri J, Levine OB, Skelly MJ, Hadley CK, Fecteau KM, Mehanna H, Nelson S, Miller J, Ghazal P, Bellotti P, Erikson DW, Geri J, Pleil KE. Rapid nongenomic estrogen signaling controls alcohol drinking behavior. bioRxiv [Preprint]. 2023 Nov 5:2023.11.02.565358. doi:10.1101/2023.11.02.565358. PMID: 37961707; PMCID: PMC10635092.
• Hámor PU, Hartmann MC, Garcia A, Liu D, Pleil KE. Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner. bioRxiv [Preprint]. 2023 Nov 5:2023.11.03.565492. doi: 10.1101/2023.11.03.565492. PMID: 37961152; PMCID:PMC10635120.
• Geeson MB, Hsiao JC, Tsamouri LP, Ball DP, Bachovchin DA. The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond. bioRxiv [Preprint]. 2023 Sep 28:2023.09.27.559829. doi: 10.1101/2023.09.27.559829. PMID:37808697; PMCID: PMC10557742.
• Rivera-Irizarry JK, Hámor PU, Rowson SA, Asfouri J, Liu D, Zallar LJ, Garcia AF, Skelly MJ, Pleil KE. Valence and salience encoding by parallel circuits from the paraventricular thalamus to the nucleus accumbens. bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547570. doi: 10.1101/2023.07.03.547570. PMID: 37461604; PMCID:PMC10349961. 
• Dumelie JG, Chen Q, Miller D, Attarwala N, Gross SS, Jaffrey SR. Biomolecular condensates create phospholipid-enriched microenvironments. Nat Chem Biol. 2023 Nov 16. doi: 10.1038/s41589-023-01474-4. Epub ahead of print. PMID: 37973889.
• Ritagliati C, Ayoub S, Balbach M, Buck J, Levin LR. In vivo characterization of sAC null sperm. Front Cell Dev Biol. 2023 Apr 21;11:1134051. doi: 10.3389/fcell.2023.1134051. PMID: 37152282; PMCID: PMC10160483.
• Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat Commun. 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. PMID: 36788210; PMCID: PMC9929232.
• Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. PMID:36724486; PMCID: PMC10149104.

• Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023 Jan
  31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. PMID: 36649711; PMCID: PMC10042216.

2022

• Wang E, Pineda JMB, Kim WJ, Chen S, Bourcier J, Stahl M, Hogg SJ, Bewersdorf JP, Han C, Singer ME, Cui D, Erickson CE, Tittley SM, Penson AV, Knorr K, Stanley RF, Rahman J, Krishnamoorthy G, Fagin JA, Creger E, McMillan E, Mak CC, Jarvis M, Bossard C, Beaupre DM, Bradley RK, Abdel-Wahab O. Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer Cell. 2023 Jan 9;41(1):164-180.e8. doi: 10.1016/j.ccell.2022.12.002. Epub 2022 Dec 22. PMID: 36563682; PMCID: PMC9839614. 

• Mayani H, Chávez-González A, Vázquez-Santillan K, Contreras J, Guzman ML. Cancer Stem Cells: Biology and Therapeutic Implications. Arch Med Res. 2022 Dec;53(8):770-784. doi: 10.1016/j.arcmed.2022.11.012. Epub 2022 Nov 30. PMID: 36462951.

• Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, Bachovchin DA. Oxidized thioredoxin-1 restrains the NLRP1 inflammasome. Sci Immunol. 2022 Nov 11;7(77):eabm7200. doi: 10.1126/sciimmunol.abm7200. Epub 2022 Nov 4. PMID: 36332009; PMCID: PMC9850498. 

• Low V, Li Z, Blenis J. Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment. Sci Signal. 2022 Nov 8;15(759):eabj4220. doi: 10.1126/scisignal.abj4220. Epub 2022 Nov 8. PMID: 36346837.

• Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S, van den Heuvel J, Steegborn C, Fushimi M, Finkin-Groner E, Myers RW, Kargman S, Liverton NJ, Huggins DJ, Meinke PT. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem. 2022 Nov 24;65(22):15208-15226. doi: 10.1021/acs.jmedchem.2c01133. Epub 2022 Nov 8. PMID: 36346696; PMCID: PMC9866367.
• Sasset L, Chowdhury KH, Manzo OL, Rubinelli L, Konrad C, Maschek JA, Manfredi G, Holland WL, Di Lorenzo A. Sphingosine-1-phosphate controls endothelial sphingolipid homeostasis via ORMDL. EMBO Rep. 2023 Jan 9;24(1):e54689. doi: 10.15252/embr.202254689. Epub 2022 Nov 21. PMID: 36408842; PMCID: PMC9827560.
• Windfelder AG, Müller FHH, Mc Larney B, Hentschel M, Böhringer AC, von Bredow CR, Leinberger FH, Kampschulte M, Maier L, von Bredow YM, Flocke V, Merzendorfer H, Krombach GA, Vilcinskas A, Grimm J, Trenczek TE, Flögel U. High-throughput screening of caterpillars as a platform to study host-microbe interactions and enteric immunity. Nat Commun. 2022 Nov 24;13(1):7216. doi: 10.1038/s41467-022-34865-7. PMID: 36433960; PMCID: PMC9700799.
• Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Gaiti F, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA. Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 Oct;54(10):1514-1526. doi: 10.1038/s41588-022-01179-9. Epub 2022 Sep 22. PMID: 36138229; PMCID: PMC10068894.
• Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. PMID: 36138187; PMCID: PMC9611506.
• Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A. Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of <i>N</i>⁶-Methyladenosine-Modified RNAs. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891. doi: 10.1021/acsptsci.2c00008. PMID: 36268123; PMCID: PMC9578143.
• Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 Oct 5;12(10):2434-2453. doi: 10.1158/2159-8290.CD-21-1631. PMID: 35904492; PMCID: PMC9533010.
• Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Van Nest SJ, Koundouros N, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews DA, tenOever BR, Cantley LC, Blenis J, Heaton NS. Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Sci Signal. 2022 Oct 25;15(757):eabm0808. doi: 10.1126/scisignal.abm0808. Epub 2022 Oct 25. PMID: 36282911; PMCID: PMC9830954.
• Murakami S, Jaffrey SR. Hidden codes in mRNA: Control of gene expression by m⁶A. Mol Cell. 2022 Jun 16;82(12):2236-2251. doi:10.1016/j.molcel.2022.05.029. PMID: 35714585; PMCID: PMC9216239.
• Koundouros N, Blenis J. Targeting mTOR in the Context of Diet and Whole-body Metabolism. Endocrinology. 2022 Jun 1;163(6):bqac041. doi:10.1210/endocr/bqac041. PMID: 35366325; PMCID: PMC9391686.
• Kim M, Chen C, Wang P, Mulvey JJ, Yang Y, Wun C, Antman-Passig M, Luo HB, Cho S, Long-Roche K, Ramanathan LV, Jagota A, Zheng M, Wang Y, Heller DA.Nat Biomed Eng. Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning. 2022 Mar;6(3):267-275. doi: 10.1038/s41551-022-00860-y. Epub 2022 Mar 17.PMID: 35301449
• Mere Del Aguila E, Tang XH, Gudas LJ. Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A. Oncol Res Treat. 2022;45(5):291-298. doi: 10.1159/000522425. Epub 2022 Feb 7. PMID: 35130553; PMCID: PMC9064920.
• Dey SK, Filonov GS, Olarerin-George AO, Jackson BT, Finley LWS, Jaffrey SR. Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag. Nat Chem Biol. 2022 Feb;18(2):180-190. doi: 10.1038/s41589-021-00925-0. Epub 2021 Dec 22. Erratum in: Nat Chem Biol. 2022 Jan 21;: PMID: 34937909; PMCID: PMC8967656.
• 2021

  • DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H.Nature. 2021 Apr;592(7856):778-783. doi: 10.1038/s41586-021-03350-4. Epub 2021 Mar 17.PMID: 33731932 

  • Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Puga Molina LC, Santi CM, Hansen JN, Wachten D, Fushimi M, Meinke PT, Buck J, Levin LR. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization. Mol Hum Reprod. 2021 Sep 1;27(9):gaab054. doi:
    10.1093/molehr/gaab054. PMID: 34463764; PMCID: PMC8473925.

  • Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J, van den Heuvel J, Steegborn C, Finkin-Groner E, Kargman S, Michino M, Foley MA, Miller M, Liverton NJ, Huggins DJ, Meinke PT. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021 Jul 14;12(8):1283-1287. doi: 10.1021/acsmedchemlett.1c00273. PMID: 34413957; PMCID: PMC8366019.

  • Cotter KA, Gallon J, Uebersax N, Rubin P, Meyer KD, Piscuoglio S, Jaffrey SR, Rubin MA. Mapping of m⁶A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. Mol Cancer Res. 2021 Jun 4. doi: 10.1158/1541-7786.MCR-21-0014. Epub ahead of print. PMID:34088870. 

  • Litke JL, Jaffrey SR. Trans ligation of RNAs to generate hybrid circular RNAs using highly efficient autocatalytic transcripts. Methods. 2021 May 13:S1046-2023(21)00135-3. doi: 10.1016/j.ymeth.2021.05.009. Epub ahead of print. PMID: 33992775.

  • Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Mo S, Barin E, Velleca A, Rohwetter TM, Patel DJ, Jaffrey SR, Kharas MG. N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021 May 12:S1535-6108(21)00225-7. doi: 10.1016/j.ccell.2021.04.017. Epub ahead of print. PMID: 34048709. 

  • Moon JD, Wu J, Dey SK, Litke JL, Li X, Kim H, Jaffrey SR. Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors. Cell Chem Biol. 2021 May 8:S2451-9456(21)00215-4. doi:10.1016/j.chembiol.2021.04.022. Epub ahead of print. PMID: 34010626. 

  • Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation. Mol Cell. 2021 May 20;81(10):2064-2075.e8. doi: 10.1016/j.molcel.2021.03.010. Epub 2021 Mar 22. PMID: 33756105.

  • Baquero J, Tang XH, Scognamiglio T, Gudas LJ. EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas. Carcinogenesis. 2021 Dec 31;42(12):1485-1495. doi: 10.1093/carcin/bgab091. PMID: 34614148; PMCID: PMC8727743.

  2020

  • Li X, Mo L, Litke JL, Dey SK, Suter SR, Jaffrey SR. Imaging Intracellular <i>S</i>-Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor. J Am Chem Soc. 2020 Aug 19;142(33):14117-14124. doi: 10.1021/jacs.0c02931. Epub 2020 Aug 7. PMID:32698574; PMCID: PMC8158784.

  • Li X, Kim H, Litke JL, Wu J, Jaffrey SR. Fluorophore-Promoted RNA Folding and Photostability Enables Imaging of Single Broccoli-Tagged mRNAs in Live Mammalian Cells. Angew Chem Int Ed Engl. 2020 Mar 9;59(11):4511-4518. doi:10.1002/anie.201914576. Epub 2020 Jan 28. PubMed PMID: 31850609.

  • Marta M, Zhang T, Scognamiglio T, Gudas LJ. Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. Carcinogenesis. 2020 Mar 2. pii: bgaa019. doi: 10.1093/carcin/bgaa019. [Epub ahead of print] PubMed PMID: 32115621.
  • van der Mijn JC, Fu L, Khani F, Zhang T, Molina AM, Barbieri CE, Chen Q, Gross SS, Gudas LJ, Nanus DM. Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma. Transl Oncol. 2020 Feb;13(2):177-185. doi: 10.1016/j.tranon.2019.10.015. Epub 2019 Dec 19. PubMed PMID: 31865180; PubMed Central PMCID: PMC6931219.
  • Kim HM, He L, Lee S, Park C, Kim DH, Han HJ, Han J, Hwang J, Cha-Molstad H,Lee KH, Ko SK, Jang JH, Ryoo IJ, Blenis J, Lee HG, Ahn JS, Kwon YT, Soung NK, KimBY. Inhibition of osteoclasts differentiation by CDC2-induced NFATc1phosphorylation. Bone. 2020 Feb;131:115153. doi: 10.1016/j.bone.2019.115153. Epub2019 Nov 12. PubMed PMID: 31730830.
  • Acosta-Ruiz A, Gutzeit VA, Skelly MJ, Meadows S, Lee J, Parekh P, Orr AG,Liston C, Pleil KE, Broichhagen J, Levitz J. Branched Photoswitchable TetheredLigands Enable Ultra-efficient Optical Control and Detection of G Protein-CoupledReceptors In Vivo. Neuron. 2020 Feb 5;105(3):446-463.e13. doi:10.1016/j.neuron.2019.10.036. Epub 2019 Nov 26. PubMed PMID: 31784287.
  • Balbach M, Buck J, Levin LR. Using an Extracellular Flux Analyzer to MeasureChanges in Glycolysis and Oxidative Phosphorylation during Mouse SpermCapacitation. J Vis Exp. 2020 Jan 22;(155). doi: 10.3791/60815. PubMed PMID:32065141. 
  • Ilter D, Blenis J, Gomes AP. Histone H3 variants at the root of metastasis.Mol Cell Oncol. 2020 Jan 10;7(2):1684128. doi: 10.1080/23723556.2019.1684128.eCollection 2020. PubMed PMID: 32158911; PubMed Central PMCID: PMC7051143.
  • Molina AM, van der Mijn JC, Christos P, Wright J, Thomas C, Dutcher JP, Nanus DM, Tagawa ST, Gudas LJ. NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma. Invest New Drugs. 2020 Jan 3. doi: 10.1007/s10637-019-00880-7. [Epub ahead of print] PubMed PMID: 31898184.

  2019

  • van der Mijn JC, Al Hussein Al Awamlh B, Islam Khan A, Posada-Calderon L, Oromendia C, Fainberg J, Alshak M, Elahjji R, Pierce H, Taylor B, Gudas LJ, Nanus DM, Molina AM, Del Pizzo J, Scherr DS. Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series. PLoS One. 2019 Dec 9;14(12):e0226285. doi: 10.1371/journal.pone.0226285. eCollection 2019. PubMed PMID: 31815952; PubMed Central PMCID: PMC6901215.
  • Grozhik AV, Olarerin-George AO, Sindelar M, Li X, Gross SS, Jaffrey SR. Antibody cross-reactivity accounts for widespread appearance of m(1)A in 5'UTRs. Nat Commun. 2019 Nov 12;10(1):5126. doi: 10.1038/s41467-019-13146-w. PubMed PMID: 31719534; PubMed Central PMCID: PMC6851129.
  • Notaras M, Allen M, Longo F, Volk N, Toth M, Li Jeon N, Klann E, Colak D. UPF2leads to degradation of dendritically targeted mRNAs to regulate synapticplasticity and cognitive function. Mol Psychiatry. 2019 Oct 21. doi:10.1038/s41380-019-0547-5. [Epub ahead of print] PubMed PMID: 31636381.
  • Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE,McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S,Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J.Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential forAcquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26.PubMed PMID: 31564638; PubMed Central PMCID: PMC6801101.
  • Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624. doi: 10.1038/s41580-019-0168-5. Epub 2019 Sep 13. Review. PubMed PMID: 31520073.
  • He L, Fei DL, Nagiec MJ, Mutvei AP, Lamprakis A, Kim BY, Blenis J. Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth andsensitivity to rapamycin. Proc Natl Acad Sci U S A. 2019 Sep24;116(39):19523-19529. doi: 10.1073/pnas.1902397116. Epub 2019 Sep 6. PubMedPMID: 31492813; PubMed Central PMCID: PMC6765302.
  • van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P, Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M, Lafontaine DLJ. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. 2019 Sep 5;47(15):7719-7733. doi: 10.1093/nar/gkz619. PubMed PMID: 31328227; PubMed Central PMCID: PMC6735865.

  • Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum ME, Jaffrey SR. Live imaging of mRNA using RNA-stabilized fluorogenic proteins. Nat Methods. 2019 

    Sep;16(9):862-865. doi: 10.1038/s41592-019-0531-7. Epub 2019 Aug 30. PubMed PMID: 31471614; PubMed Central PMCID: PMC6719798.
  • Dey SK, Jaffrey SR. RIBOTACs: Small Molecules Target RNA for Degradation. Cell Chem Biol. 2019 Aug 15;26(8):1047-1049. doi: 10.1016/j.chembiol.2019.07.015. PubMed PMID: 31419417.
  • Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG. m(6)A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Rep. 2019 Aug 13;28(7):1703-1716.e6. doi: 10.1016/j.celrep.2019.07.032. PubMed PMID: 31412241; PubMed Central PMCID: PMC6818972.
  • Boulias K, Toczydłowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome. Mol Cell. 2019 Aug 8;75(3):631-643.e8. doi: 10.1016/j.molcel.2019.06.006. Epub 2019 Jul 3. PubMed PMID: 31279658; PubMed Central PMCID: PMC6703822.
  • Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR. m(6)A enhances the phase separation potential of mRNA. Nature. 2019 Jul;571(7765):424-428. doi: 10.1038/s41586-019-1374-1. Epub 2019 Jul 10. PubMed PMID: 31292544; PubMed Central PMCID: PMC6662915.
  • Yang Y, Mohammed FS, Zhang N, Sauve AA. Dihydronicotinamide riboside is apotent NAD(+) concentration enhancer in vitro and in vivo. J Biol Chem. 2019 Jun 7;294(23):9295-9307. doi: 10.1074/jbc.RA118.005772. Epub 2019 Apr 4. PubMed PMID:30948509; PubMed Central PMCID: PMC6556581.
  • Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur JJ, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, Jaffrey SR. FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis. Nat Chem Biol. 2019 Apr;15(4):340-347. doi: 10.1038/s41589-019-0231-8. Epub 2019 Feb 18. PubMed PMID:30778204; PubMed Central PMCID: PMC6984009.
  • van der Mijn JC, Al Hussein Al Awamlh B, Islam Khan A, Posada-Calderon L, Oromendia C, Fainberg J, Alshak M, Elahjji R, Pierce H, Taylor B, Gudas LJ, Nanus DM, Molina AM, Del Pizzo J, Scherr DS. Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series. PLoS One. 2019 Dec 9;14(12):e0226285. doi: 10.1371/journal.pone.0226285. eCollection 2019. PubMed PMID: 31815952; PubMed Central PMCID: PMC6901215.
  • Hawley BR, Jaffrey SR. Transcriptome-Wide Mapping of m(6) A and m(6) Am at Single-Nucleotide Resolution Using miCLIP. Curr Protoc Mol Biol. 2019 Apr;126(1):e88. doi: 10.1002/cpmb.88. Epub 2019 Mar 15. PubMed PMID: 30874375; PubMed Central PMCID: PMC6422687.
  • Osei-Sarfo K, Gudas LJ. Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells. PLoS One. 2019 Apr 12;14(4):e0215234. doi: 10.1371/journal.pone.0215234. eCollection 2019. PubMed PMID: 30978209; PubMed Central PMCID: PMC6461257.
  • Serio RN, Laursen KB, Urvalek AM, Gross SS, Gudas LJ. Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ. J Biol Chem. 2019 Apr 5;294(14):5536-5548. doi: 10.1074/jbc.RA118.007153. Epub 2019 Feb 8. PubMed PMID: 30737277; PubMed Central PMCID: PMC6462535.
  • Filonov GS, Song W, Jaffrey SR. Spectral Tuning by a Single Nucleotide Controls the Fluorescence Properties of a Fluorogenic Aptamer. Biochemistry. 2019 Mar 26;58(12):1560-1564. doi: 10.1021/acs.biochem.9b00048. Epub 2019 Mar 11. PubMed PMID: 30838859.
  •  You M, Litke JL, Wu R, Jaffrey SR. Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator. Cell Chem Biol. 2019 Apr 18;26(4):471-481.e3. doi: 10.1016/j.chembiol.2019.01.005. Epub 2019 Feb 14. PubMed PMID: 30773480; PubMed Central PMCID: PMC6474789.
  • Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO. ERK2 regulatesepithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1activation. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2967-2976. doi:10.1073/pnas.1811923116. Epub 2019 Feb 6. PubMed PMID: 30728292; PubMed CentralPMCID: PMC6386703.
  • Melis M, Tang XH, Trasino SE, Patel VM, Stummer DJ, Jessurun J, Gudas LJ. Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease. PLoS One. 2019 Jan 24;14(1):e0211071. doi: 10.1371/journal.pone.0211071. eCollection 2019. PubMed PMID: 30677086; PubMed Central PMCID: PMC6345457.

  2018

  • Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhaes A, Ferreira JA, Osorio H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID:29459780.
  • Schild T, Low V, Blenis J, Gomes AP. Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer Cell. 2018 Mar 12;33(3):347-354. doi: 10.1016/j.ccell.2018.02.001. PMID:29533780.
  • Maik-Rachline G, Zehorai E, Hanoch T, Blenis J, Seger R. The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer. Sci Signal. 2018 Apr 10;11(525). pii: eaao3428. doi: 10.1126/scisignal.aao3428. PMID:29636389.
  • He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A Islam T, Yu Y, Asara JM, Kim BY, Blenis J. mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Mol Cell. 2018 Jun 7;70(5):949-960.e4. doi: 10.1016/j.molcel.2018.04.024. Epub 2018 May 31. PMID:29861159.
  • Rosenzweig A, Blenis J, Gomes AP. Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? Front Cell Dev Biol. 2018 Aug 15;6:90. doi: 10.3389/fcell.2018.00090. eCollection 2018. PMID:30159313.
  • Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein R, Knauf JA, Ratsch G, Fagin JA. EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC. Cancer Discov. 2018 Oct 10. pii: CD-18-0606. doi: 10.1158/2159-8290.CD-18-0606. [Epub ahead of print] PMID:30305285.
  • Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 2018 Nov 29;175(6):1546-1560.e17. doi: 10.1016/j.cell.2018.09.041. PMID:30500537.
  • Toth M. The other side of the coin: Hypersociability. Genes Brain Behav. 2018 Aug 13:e12512. doi: 10.1111/gbb.12512. [Epub ahead of print] PMID:30101538.
  • Pleil KE, Skelly MJ. CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety. Alcohol. 2018 Nov;72:33-47. doi: 10.1016/j.alcohol.2018.01.007. Epub 2018 Feb 2. PMID:30217435.
  • Jaffrey SR, Wilkinson MF. Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease. Nat Rev Neurosci. 2018 Dec;19(12):715-728. doi: 10.1038/s41583-018-0079-z. PMID:30410025.
  • Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. PMID:30341316.
  • Sindelar M, Dyke JP, Deeb RS, Sondhi D, Kaminsky SM, Kosofsky BE, Ballon DJ, Crystal RG, Gross SS. Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease). Sci Rep. 2018 Oct 15;8(1):15229. doi: 10.1038/s41598-018-33449-0. PMID:30323181.
  • Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmuller G, Elemento O, Gross SS, Suhre K. Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis. Cancer Lett. 2018 Aug 28;430:133-147. doi: 10.1016/j.canlet.2018.05.017. Epub 2018 May 17. PMID:29777783.
  • Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J, Wakamatsu K, Ito S, Zippin JH. Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH. Sci Signal. 2018 Nov 6;11(555). pii: eaau7987. doi: 10.1126/scisignal.aau7987. PMID:30401788.
  • Trasino SE, Tang XH , Shevchuk MM, Choi ME, Gudas LJ. Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor B2 Agonist. J Pharmacol Exp Ther. 2018 Jul 27. pii: jpet.118.249375. doi: 10.1124/jpet.118.249375. PMID:30054312.
  • Zhang N, Sauve AA. Regulatory Effects of NAD+ Metabolic Pathways on Sirtuin Activity. Prog Mol Biol Transl Sci. 2018;154:71-104. doi: 10.1016/bs.pmbts.2017.11.012. PMID:29413178.
  • Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001. PMID:29514072.
  • Reidenberg MM. Diagnosis Drift and Its Contribution to Polypharmacy. Clin Pharmacol Ther. 2018 Apr;103(4):556-557. doi: 10.1002/cpt.858. Epub 2017 Oct 3. PMID:28971479.
  • Marino A, Levi R. Salvaging the ischemic heart: Gi-coupled receptors in mast cells activate a PKC/ALDH2 pathway providing anti-RAS cardioprotection. Curr Med Chem. 2018 Feb 13. doi: 10.2174/0929867325666180214115127. PMID:29446730.
  • Marino A, Sakamoto T, Tang XH, Gudas LJ, Levi R. A RETINOIC ACID P2-RECEPTOR AGONIST EXERTS CARDIOPROTECTIVE EFFECTS. J Pharmacol Exp Ther. 2018 Jun 15. pii: jpet.118.250605. doi: 10.1124/jpet.118.250605. PMID:29907698.
  • Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M. Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. Cell Metab. 2018 May 1;27(5):1007-1025.e5. doi: 10.1016/j.cmet.2018.03.002. Epub 2018 Apr 12. PMID:29657030.
  • Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmuller G, Elemento O, Gross SS, Suhre K. Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis. Cancer Lett. 2018 Aug 28;430:133-147. doi: 10.1016/j.canlet.2018.05.017. Epub 2018 May 17. PMID:29777783
  • Wiggins SV, Steegborn C, Levin LR, Buck J. Pharmacological modulation of the CO2/HCO3-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase. Pharmacol Ther. 2018 May 26. pii: S0163-7258(18)30088-3. doi: 10.1016/j.pharmthera.2018.05.008. [Epub ahead of print]. PMID:29807057.
  • Sureshbabu A, Patino E, Ma KC, Laursen K, Finkelsztein EJ, Akchurin O, Muthukumar T, Ryter SW, Gudas L, Choi AMK, Choi ME. RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. JCI Insight. 2018 Jun 7;3(11). pii: 98411. doi: 10.1172/jci.insight.98411. [Epub ahead of print]. PMID:29875323.
  • Laursen KB, Gudas LJ. Combinatorial knockout of RARa, RAR?, and RARy completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells. J Biol Chem. 2018 May 30. pii: jbc.RA118.001951. doi: 10.1074/jbc.RA118.001951. [Epub ahead of print]. PMID:29848550.
  • Lee M, Gudas LJ, Saavedra HI. Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays. Methods Mol Biol. 2018;1726:143-151. doi: 10.1007/978-1-4939-7565-5_13. PMID:29468550.
  • Mauer J, Jaffrey SR. FTO, m6 Am , and the hypothesis of reversible epitranscriptomic mRNA modifications. FEBS Lett. 2018 May 12. doi: 10.1002/1873-3468.13092. [Epub ahead of print]. PMID:29754392.
  • Grozhik AV, Jaffrey SR . Distinguishing RNA modifications from noise in epitranscriptome maps. Nat Chem Biol. 2018 Feb 14;14(3):215-225. doi: 10.1038/nchembio.2546. PMID:29443978.
  • Kim JY, Deglincerti A, Jaffrey SR. A Staufen1-mediated decay pathway influences the local transcriptome in axons. Translation (Austin). 2017 Dec 12;5(2):e1414016. doi: 10.1080/21690731.2017.1414016. eCollection 2017. PMID:29416957.
  • Jaffrey SR. RNA-Based Fluorescent Biosensors for Detecting Metabolites in vitro and in Living Cells. Adv Pharmacol. 2018;82:187-203. doi: 10.1016/bs.apha.2017.09.005. Epub 2017 Oct 25. PMID:29413520.
  • Wu B, Su S, Patil DP, Liu H, Gan J, Jaffrey SR, Ma J. Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun. 2018 Jan 29;9(1):420. doi: 10.1038/s41467-017-02770-z. PMID: 29379020.
  • Patil DP, Pickering BF, Jaffrey SR Reading m6A in the Transcriptome: m6A-Binding Proteins. Trends Cell Biol. 2018 Feb;28(2):113-127. doi: 10.1016/j.tcb.2017.10.001. Epub 2017 Nov 2.PMID: 29103884.

  2017

  • Malhotra VT, Glare P, Tan KS, Wills J, Gulati A, Puttanniah V, Hung J, Cubert K, Inturrisi C . The Tri-Institutional Pain Registry-Analysis of Outpatient Pain Management at a Specialized Cancer Center. Pain Med. 2017 Dec 1;18(12):2474-2484. doi: 10.1093/pm/pnx136. PMID:29016931.
  • Zhang N, Sauve AA. Synthesis of P-Nicotinamide Riboside Using an Efficient Two-Step Methodology. Curr Protoc Nucleic Acid Chem. 2017 Dec 24;71:14.14.1-14.14.9. doi: 10.1002/cpnc.43. PMID:29275540.
  • Bath KG, Russo SJ, Pleil KE, Wohleb ES, Duman RS, Radley JJ. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. Neurobiol Stress. 2017 May 6;7:137-151. doi: 10.1016/j.ynstr.2017.05.001. eCollection 2017 Dec. PMID:29276735.
  • Witkin LR, Zylberger D, Mehta N, Hindenlang M, Johnson C, Kean J, Horn SD, Inturrisi CE. Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain. J Pain. 2017 May;18(5):583-596. doi: 10.1016/j.jpain.2016.12.018. Epub 2017 Jan 12. PMID:28088507.
  • Zhou Y, Schwartz BI, Giza J, Gross SS, Lee FS, Kreek MJ. Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice. Psychopharmacology (Berl). 2017 Oct;234(19):2955-2970. doi: 10.1007/s00213-017-4691-9. Epub 2017 Jul 20. PMID:28730283.
  • Konrad C, Kawamata H, Bredvik KG, Arreguin AJ, Cajamarca SA, Hupf JC, Ravits JM, Miller TM, Maragakis NJ, Hales CM, Glass JD, Gross S, Mitsumoto H, Manfredi G. Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients. Mol Neurodegener. 2017 Oct 24;12(1):76. doi: 10.1186/s13024-017-0217-5. PMID:29065921.
  • Nuriel T, Angulo SL, Khan U1, Ashok A1, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE9. Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0. PMID:29133888.
  • Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell Rep. 2017 Nov 14;21(7):1795-1808. doi: 10.1016/j.celrep.2017.10.072. PMID:29141214.
  • Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magrane J, Starkov A, Buck J, Levin LR, Manfredi G. Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function. J Cell Sci. 2017 Nov 1;130(21):3713-3727. doi: 10.1242/jcs.206318. Epub 2017 Sep 1. PMID:28864766.
  • Grozhik AV, Jaffrey SR. Epitranscriptomics: Shrinking maps of RNA modifications. Nature. 2017 Nov 9;551(7679):174-176. doi: 10.1038/nature24156. Epub 2017 Oct 25. PMID: 29072301 .
  • Dumelie JG, Jaffrey SR . Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq. Elife. 2017 Oct 26;6. pii: e28306. doi: 10.7554/eLife.28306. PMID: 29072160 .
  • Warner KD, Sjekloca L, Song W, Filonov GS, Jaffrey SR , Ferre-D'Amare AR. A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 2017 Nov;13(11):1195-1201. doi: 10.1038/nchembio.2475. Epub 2017 Sep 25. PMID: 28945234.
  • Song W, Filonov GS, Kim H, Hirsch M, Li X, Moon JD, Jaffrey SR. Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nat Chem Biol. 2017 Nov;13(11):1187-1194. doi: 10.1038/nchembio.2477. Epub 2017 Sep 25. PMID: 28945233.
  • Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18. PMID: 28920958.
  • Meyer KD, Jaffrey SR. Rethinking m6A Readers, Writers, and Erasers. Annu Rev Cell Dev Biol. 2017 Oct 6;33:319-342. doi: 10.1146/annurev-cellbio-100616-060758. Epub 2017 Jul 31. PMID: 28759256.
  • Zupan B, Liu B, Taki F, Toth JG, Toth M . Maternal Brain TNF-a Programs Innate Fear in the Offspring. Curr Biol. 2017 Nov 21. pii: S0960-9822(17)31439-2. doi: 10.1016/j.cub.2017.10.071. [Epub ahead of print]. PMID: 29199072.
  • Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M , Yu WH, Muller FL, Paik J. FOXO protects against age-progressive axonal degeneration. Aging Cell. 2017 Nov 26. doi: 10.1111/acel.12701. [Epub ahead of print. PMID: 29178390.
  • Diani-Moore S, Shoots J, Singh R , Zuk JB, Rifkind AB . NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268. doi: 10.1038/s41598-017-02332-9. PMID:28536482
  • Marino A, Sakamoto T, Robador PA, Tomita K, Levi R .S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2. J Pharmacol Exp Ther. 2017 Aug;362(2):230-242. doi: 10.1124/jpet.117.241976. Epub 2017 May 12. PMID:28500264
  • Mauer J , Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS , Elemento O, Debart F, Kiledjian M, Jaffrey SR . Reversible methylation of m6Am in the 5' cap controls mRNA stability. Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21. PMID:28002401
  • Jaffrey SR, Kharas MG . Emerging links between m6A and misregulated mRNA methylation in cancer. Genome Med. 2017 Jan 12;9(1):2. doi: 10.1186/s13073-016-0395-8. PMID: 28081722
  • Olarerin-George AO, Jaffrey SR. MetaPlotR: a Perl/R pipeline for plotting metagenes of nucleotide modifications and other transcriptomic sites. Bioinformatics. 2017 May 15;33(10):1563-1564. doi: 10.1093/bioinformatics/btx002. PMID:28158328
  • Witkin LR, Zylberger D, Mehta N, Hindenlang M , Johnson C, Kean J, Horn SD, Inturrisi CE. Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain. J Pain. 2017 May;18(5):583-596. doi: 10.1016/j.jpain.2016.12.018. Epub 2017 Jan 12. PMID:28088507
  • Grozhik AV, Linder B, Olarerin-George AO, Jaffrey SR. Mapping m6A at Individual-Nucleotide Resolution Using Crosslinking and Immunoprecipitation (miCLIP). Methods Mol Biol. 2017;1562:55-78. doi: 10.1007/978-1-4939-6807-7_5.PMID:28349454
  • Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. The m6A pathway facilitates sex determination in Drosophila. Nat Commun. 2017 Jul 4;8:15737. doi: 10.1038/ncomms15737.PMID:28675155
  • Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD. Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors . J Ocul Pharmacol Ther. 2017 Jul 7. doi: 10.1089/jop.2017.0027. [Epub ahead of print]PMID:28686538

  2016

  • Cea ME, Reid MC, Inturrisi C, Witkin LR, Prigerson HG, Bao Y. Pain Assessment, Management, and Control Among Patients 65 Years or Older Receiving Hospice Care in the U.S. J Pain Symptom Manage. 2016 Nov;52(5):663-672. doi: 10.1016/j.jpainsymman.2016.05.020. Epub 2016 Sep 29. PMID:27693900.
  • Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, van den Brink M, Toth M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nat Commun. 2016 May 13;7:11492. doi: 10.1038/ncomms11492. PMID: 27173585
  • Sharma A, Klein SS, Barboza L, Lohdi N, Toth M. Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification. J Neurosci. 2016 Feb 3;36(5):1711-22. doi: 10.1523/JNEUROSCI.4037-15.2016. PMID: 26843651
  • Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mazala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Canto C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139. PMID: 27798264
  • Yang Y, Sauve AA. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy. Biochim Biophys Acta. 2016 Dec;1864(12):1787-1800. doi: 10.1016/j.bbapap.2016.06.014. Epub 2016 Jun 29. PMID: 27374990
  • Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze JF, Gudas LJ, Cowley SM, Nagy L. OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation. Mol Cell. 2016 Aug 18;63(4):647-661. doi: 10.1016/j.molcel.2016.06.039. Epub 2016 Aug 4. PMID: 27499297.
  • Trasino SE, Tang XH, Jessurun J, Gudas LJ. A retinoic acid receptor B2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease. J Mol Med (Berl). 2016 Oct;94(10):1143-1151. Epub 2016 Jun 6. PMID: 27271256.
  • Minton DR, Fu L, Mongan NP, Shevchuk MM, Nanus DM, Gudas LJ. Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2016 Jun 1;22(11):2791-801. doi: 10.1158/1078-0432.CCR-15-1511. Epub 2016 Jan 18. PMID: 26783287.
  • Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16. PMID:26404765.
  • Meyer KD, Jaffrey SR. Expanding the diversity of DNA base modifications with N (6)-methyldeoxyadenosine. Genome Biol. 2016 Jan 13;17(1):5. doi: 10.1186/s13059-016-0874-7. PMID:26762117.
  • Arunachalam G, Lakshmanan AP, Samuel SM, Triggle CR, Ding H. Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin. J Pharmacol Exp Ther. 2016 Feb;356(2):314-23. doi: 10.1124/jpet.115.226894. Epub 2015 Nov 18. PMID:26582729.
  • Kim JY, Jaffrey SR. Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis. J Cell Biol. 2016 Mar 28;212(7):751-3. doi: 10.1083/jcb.201603028. PMID:27022088.
  • Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C. Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site. J Biol Chem. 2016 Mar 9. pii: jbc.M115.708255. [Epub ahead of print] PMID:26961873.
  • Filonov GS, Jaffrey SR. RNA Imaging with Dimeric Broccoli in Live Bacterial and Mammalian Cells. Curr Protoc Chem Biol. 2016 Mar 16;8(1):1-28. doi: 10.1002/9780470559277.ch150174. PMID:26995352.

  2015

  • Reidenberg MM. Are we moving towards a new definition of essential medicines? J Pharmacol Pharmacother. 2015 Oct-Dec;6(4):233. doi: 10.4103/0976-500X.171874. PMID:26816479.
  • Li W, Sauve AA . NAD* content and its role in mitochondria. Methods Mol Biol. 2015;1241:39-48. doi: 10.1007/978-1-4939-1875-1_4. PMID: 25308486.
  • Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC. Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. Cell Rep. 2015 Oct 20;13(3):533-545. doi: 10.1016/j.celrep.2015.09.023. Epub 2015 Oct 8. PMID: 26456827.
  • You M,Jaffrey SR. Designing optogenetically controlled RNA for regulating biological systems. Ann N Y Acad Sci. 2015 Sep;1352:13-9. doi: 10.1111/nyas.12660. Epub 2015 Mar 10. PMID:25758022.
  • You M, Litke JL, Jaffrey SR. Imaging metabolite dynamics in living cells using a Spinach-based riboswitch. Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2756-65. doi: 10.1073/pnas.1504354112. Epub 2015 May 11. PMID:25964329.
  • You M, Jaffrey SR. Structure and Mechanism of RNA Mimics of Green Fluorescent Protein. Annu Rev Biophys. 2015;44:187-206. doi: 10.1146/annurev-biophys-060414-033954. PMID:26098513.
  • Trasino SE, Benoit YD, Gudas LJ. Vitamin A deficiency causes hyperglycemia and loss of pancreatic B-cell mass. J Biol Chem. 2015 Jan 16;290(3):1456-73. doi: 10.1074/jbc.M114.616763. Epub 2014 Dec 1. PMID:25451926.
  • Trasino SE, Tang XH, Jessurun J, Gudas LJ. Obesity Leads to Tissue, but not Serum Vitamin A Deficiency. Sci Rep. 2015 Nov 2;5:15893. doi: 10.1038/srep15893. PMID:26522079.
  • Trasino SE, Gudas LJ. Vitamin A: a missing link in diabetes? Diabetes Manag (Lond). 2015;5(5):359-367. PMID:26535059.
  • Tang XH, Urvalek AM, Osei-Sarfo K, Zhang T, Scognamiglio T, Gudas LJ. Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology. Oncotarget. 2015 Sep 15;6(27):24424-35. PMID:26110572.
  • Osei-Sarfo K, Urvalek AM, Tang XH, Scognamiglio T, Gudas LJ. Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model. Oncotarget. 2015 Mar 20;6(8):6040-52. PMID:25714027.
  • Urvalek AM, Osei-Sarfo K, Tang XH, Zhang T, Scognamiglio T, Gudas LJ. Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis. Alcohol Clin Exp Res. 2015 Aug;39(8):1360-72. doi: 10.1111/acer.12772. PMID:26207766.
  • Meyer KD, Patil DP,, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB, Jaffrey SR. 5' UTR m(6)A Promotes Cap-Independent Translation. Cell. 2015 Nov 5;163(4):999-1010. doi: 10.1016/j.cell.2015.10.012. Epub 2015 Oct 22. PMID:26593424.
  • Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. FASEB J. 2015 Jan;29(1):61-9. doi: 10.1096/fj.14-261867. Epub 2014 Oct 15. PMID:25318477.
  • Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat Methods. 2015 Aug;12(8):767-72. doi: 10.1038/nmeth.3453. Epub 2015 Jun 29. PMID:26121403.
  • Ghosh S, Lakshmanan AP, Hwang MJ, Kubba H, Mushannen A, Triggle CR, Ding H. Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. Biochem Pharmacol. 2015 Dec 1;98(3):412-21. doi: 10.1016/j.bcp.2015.10.008. Epub 2015 Oct 20. PMID:26467186.
  • Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR, Matera AG. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 2015 Sep;21(9):1554-65. doi: 10.1261/rna.052944.115. Epub 2015 Jul 20. PMID:26194134.
  • Filonov GS, Kam CW, Song W, Jaffrey SR. In-gel imaging of RNA processing using broccoli reveals optimal aptamer expression strategies. Chem Biol. 2015 May 21;22(5):649-60. doi: 10.1016/j.chembiol.2015.04.018. PMID:26000751.

  2014

  • Arunachalam G, Samuel SM, Marei I, Ding H, Triggle CR. Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol. 2014 Jan;171(2):523-35. doi: 10.1111/bph.12496. PMID:24372553.
  • Osei-Sarfo K, Gudas LJ. Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway. Stem Cells. 2014 Aug;32(8):2061-71. doi: 10.1002/stem.1706. PMID:24648413.
  • Tang XH, Osei-Sarfo K, Urvalek AM, Zhang T, Scognamiglio T, Gudas LJ. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12. doi: 10.1073/pnas.1404828111. Epub 2014 Jun 3. PMID:24927566.
  • Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014 May;15(5):313-26. doi: 10.1038/nrm3785. Epub 2014 Apr 9. PMID:24713629.
  • Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R. Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C E-dependent aldehyde dehydrogenase type-2 activation. J Pharmacol Exp Ther. 2014 Jun;349(3):508-17. doi: 10.1124/jpet.114.214122. Epub 2014 Apr 2. PMID:24696042.
  • Filonov GS, Moon JD, Svensen N, Jaffrey SR. Broccoli: rapid selection of an RNA mimic of green fluorescent protein by fluorescence-based selection and directed evolution. J Am Chem Soc. 2014 Nov 19;136(46):16299-308. doi: 10.1021/ja508478x. Epub 2014 Nov 5. PMID:25337688.
  • Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr Biol. 2014 Oct 6;24(19):2274-80. doi: 10.1016/j.cub.2014.08.007. Epub 2014 Sep 11. PMID:25220053.
  • Ismailoglu I, Chen Q, Popowski M, Yang L, Gross SS, Brivanlou AH. Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells. Dev Biol. 2014 Jul 15;391(2):230-40. doi: 10.1016/j.ydbio.2014.04.005. Epub 2014 Apr 26. PMID:24780625.

  2013

  • Osei-Sarfo K, Tang XH, Urvalek AM, Scognamiglio T, Gudas LJ. The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC. Carcinogenesis. 2013 Nov;34(11):2673-81. doi: 10.1093/carcin/bgt223. Epub 2013 Jun 19. PMID:23784083.

  2012

  • Basha B, Samuel SM, Triggle CR, Ding H. Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Exp Diabetes Res. 2012;2012:481840. doi: 10.1155/2012/481840. Epub 2012 Feb 28. PMID: 22474423.
  • Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H. The endothelium: influencing vascular smooth muscle in many ways. Can J Physiol Pharmacol. 2012 Jun;90(6):713-38. doi: 10.1139/y2012-073. Epub 2012 May 24. PMID:22625870.
  • Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17. PMID:22608085.

  2010

  • Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic {gamma}-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010 Nov 29. [Epub ahead of print] PMCID: PMC3003001
  • Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010;67(5):769-80. PMCID: PMC2947312
  • Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010Sep;22(9):1300-7. PMID: 20406683
  • Kolesnick R, van den Brink M, Heller G, Rotolo JA. (2010) Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Jan 14;115(2):436. PMID: 20075176.
  • Luo W, Sun W, Taldone T, Rodina A, Chiosis G. (2010) Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener. 2010 Jun 3;5(1):24. PMID: 20525284
  • Lee MY, Lu A, Gudas LJ. (2010) Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. J Cell Physiol. 2010 Jul;224(1):17-27.PMID: 20232320
  • Trzupek JD, Lee D, Crowley BM, Marathias VM, Danishefsky SJ. (2010) Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet-Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan. J Am Chem Soc. 2010 Jun 23;132(24):8506-12. PMID: 20509657
  • Jeske S, Tagawa ST, Olowokure O, Selzer J, Giannakakou P, Nanus DM. (2010) Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer. Urol Oncol. 2010 May 5. [Epub ahead of print] PMID: 20451413
  • Tresguerres M, Levin LR, Buck J, Grosell M. (2010) Modulation of NaCl absorption by [HCO3-] in the marine teleost intestine is mediated by soluble adenylyl cyclase. Am J Physiol Regul Integr Comp Physiol. 2010 Apr 21. [Epub ahead of print] PMID: 20410468
  • Chanel-Vos C, Giannakakou P. (2010) CENP-E checks in microtubule-drug resistance. Cell Cycle. 2010 Apr 15;9(8). PMID: 20421712
  • Lee D, Danishefsky SJ. (2010) Cascade resulting in the reductive ethynylation of aldehydes: dissection of its components. J Am Chem Soc. 2010 Mar 31;132(12):4427-30. PMID: 20201522
  • Lee JH, Kim WH, Danishefsky SJ. (2010) An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position. Tetrahedron Lett. 2010 Mar 3;51(9):1252. PMID: 20174450
  • Wu X, Stockdill JL, Wang P, Danishefsky SJ. (2010) Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. J Am Chem Soc. 2010 Mar 31;132(12):4098-100. PMID: 20199071
  • Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS. (2010) Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90. J Org Chem. 2010 May 7;75(9):2820-35. PMID: 20392070
  • David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM. (2010) Phase I trial of ATRA-IV and depakote in patients with advanced solid tumor malignancies. Cancer Biol Ther. 2010 May 8;9(9). PMID: 20200483
  • Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ. (2010) The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regen Med. 2010 Mar;5(2):201-20.PMID: 20210581
  • Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF. (2010) Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3351-5. .PMID: 19966310
  • Perl NR, Ide ND, Prajapati S, Perfect HH, Durón SG, Gin DY. (2010) Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine. J Am Chem Soc. 2010 Feb 17;132(6):1802-3. PMID: 20095555
  • Holland JP, Caldas-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS. (2010) Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. PLoS One. 2010 Jan 25;5(1):e8859.PMID: 20111600
  • Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. (2010) Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. PMID: 20018667

   

  2009 

  • Oh J.E. Zupan B., Gross S., Toth M. (2009) Paradoxical anxiogenic response of juvenile mice to fluoxetine. Neuropsychopharmacology Sep;34(10):2197-207. PMID 19440190
  • Kan C, Danishefsky SJ. (2009) Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron. 2009 Nov 7;65(45):9047-9065.PMID: 20161377
  • Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. (2009) regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog. OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs. Stem Cells Dev 2009 Sep;18(7):1093-108. PMID: 19480567
  • Zhang T., Berrocal J.G., Frizzell K.M., Gamble M.J., Dumond M.E., Krishnakumar R., Yang T., Sauve A.A., Kraus W.L. (2009) Enzymes in the NAD+ salvage pathway regulate SIRT-1 activity at target gene promoters. J Biol Chem Jul 24;284(30):20408-17. PMID: 19478080
  • Tang X.H., Su D., Albert M., Scognamiglio T., Gudas L.J. (2009) Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther Jul6;8(13)
  • Breinig M, Caldas-Lopes E, Goeppert B, Malz M, Rieker R, Bergmann F, Schirmacher P, Mayer M, Chiosis G, Kern MA. (2009) Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma. Hepatology. 2009 Jul;50(1):102-12. PMID: 19441108
  • Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. (2009) A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nat Med. 2009 Dec;15(12):1369-76. Epub 2009 Nov 22. PMID: 19966776
  • Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. . PMID: 19766101
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. (2009) Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22;114(17):3693-706. .PMID: 19666872
  • Taldone T, Chiosis G. (2009) Purine-scaffold Hsp90 inhibitors. Curr Top Med Chem. 2009;9(15):1436-46. Review. PMID: 19860732
  • Tang XH, Albert M, Scognamiglio T, Gudas LJ. (2009) A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1100-10. PMID: 19952362
  • Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2009) A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem. 2009;24(3-4):219-30. PMID: 19710537
  • Liu L, Tang XH, Scognamiglio T, Gudas LJ. (2009) Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice. J Nutr Biochem. 2009 Nov 30. [Epub ahead of print] PMID: 19954945
  • Xu G, Shin SB, Jaffrey SR. (2009) Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19310-5. PMID: 19892738
  • Herold KF, Nau C, Ouyang W, Hemmings HC Jr. (2009) Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Sep;111(3):591-9 .PMID: 19672182
  • Hengst U, Deglincerti A, Kim HJ, Jeon NL, Jaffrey SR. (2009) Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nat Cell Biol. 2009 Aug;11(8):1024-30. PMID: 19620967
  • Caldas-Lopez E., Cerchietti L, Ahn J.H., Clement C.C., Robles A.I., Rodina A., Moulick K., Taldone T., Gozman A., Guo Y., Wu N., de Stanchina E., White J., Gross S.S. Ma Y., Varticovski L., Melnick A., Chiosis G. (2009) Hsp90 inhibitor PU-H71 a multimodal inhibitor og malignancy, includes complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A May 19;106(20):8366-73. PMID 19416831
  • Zhou J., Vos C.C., Gjyrezi A., Yoshida M., Khuri F.R., Tamonoi F., Giannakakou P. (2009) The protein farnesyltrasferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem Apr 10;284(15):9648-55. PMID 19228685
  • Garraway S.M., Xu Q., Inturrisi C.E. (2009) siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats. J Pain Apr;10(4):380-90. PMID 19185544
  • Hao G., Wang D., Gu J., Chen Q., Gross S.S., Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spoctrometric identification of protein citrullination. J Am Soc Mass Spectrom Apr;20(4):723-7. PMID 19200748
  • Ouyang W, Herold KF, Hemmings HC Jr. (2009) Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology. 2009 Mar;110(3):582-90.PMID: 19225394
  • Tao H., Kang Y., Taldone T., Chiosis G.(2009) Microwave-assisted one step synthesis of 8-arylmethyl-9H-puring-6-amines. Bioorg Med Chem Lett. Jan 15;19(2):415-17. PMID 19058963.
  • Rotolo J.A., Kolesnick R., Fuks Z. (2009) Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys Jan1;73(1):6-8. PMID 19100919

  2008

  • Farrell J., Ramos L.S., Tresguerres M., Kamentsky M., Levin L.R., Buck J. Somatic "soluble" adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex "knockout" mice. PLoS ONE Sep22;3(9):e3251.
  • Ramos L.S., Zippin J.H., Kamenetsky M., Buck J., Levin L.R. (2008) Glucose and GLP-1 Stimulate cAMP production via distinct adenylyl cyclase in INS-1E insulinoma cells. J Gen Physiol Sep;132(3):329-38. PMID 18695009
  • Gomez-Nunez M., Haro K.J., Dao T., Chau D., Won A., Escobar-Alvarez S., Zakhaleva V., Korontsvit T., Gin D.Y., Scheinberg D.A. (2008) Non- Natural and photo-reactive amino acids as biochemical probes of immune function. PLoS ONE 3(12):e3938. PMID 19079589
  • Bultman M.S., Ma J., Gin D.Y. (2008) Synthetic access to the chlorocyclopentane cores of the proposed original and revised structures of palau'amine. Angew Chem Int Ed Engl 47(36):6821-4. PMID 18655078
  • Maslak PG, Dao T, Gomez M, Chanel S, Packin J, Korontsvit T, Zakhaleva V, Pinilla-Ibarz J, Berman E, Scheinberg DA. A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease. Leukemia Aug;22(8):1613-6. PMID: 18256684
  • Mun J., Wang Y., Voll R.J., Escuin-Borras D., Giannakakou P., Goodman M.M. (2008) Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol and radiosynthesis of 2-[(18)F]fluorothoxyestradiol for positron emission tomography. Nucl Med Biol Jul;35(5):615-22. PMID 18589306
  • Kano S., Tyler E., Salazar-Rodriguez M., Estephan R., Mackins C.J., Veerappan A., reid A.C., Silver R.B., Levi R. (2008) Immediate hypersensitivity elicits renin release from cardiac mast cells. Intl Arch Allergy Immunol; 146:71-75. PMID 18087164
  • Veerappan A., Reid A., Estephan R., O'Connor N., Thadani-Mulero M., Salazar-Rodriguez M., Levi R., Silver R.B. (2008) Mast cell renin and a local renin-angiotensin system in the airway: Role of bronchoconstriction. Proc Natl Acad Sci USA 105;1315-1320. PMID 18202178
  • Morrey C., Estephan R, Abbott GW, Levi R. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther 2008 Sep;326(3);871-8. PMID: 18523159
  • Cox LJ, Hengst U, Gurskaya NG, Lukyanov KA, Jaffrey SR. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol. 2008 Feb;10(2):149-59. Epub 2008 Jan 13. PMID: 18193038
  • Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. PMID: 18191336
  • Cheng HT, Suzuki M, Hegarty DM, Xu Q, Weyerbacher AR, South SM, Ohata M, Inturrisi CE. Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn. Neuroscience. Aug 6;155(3):948-58. PMID: 18621103
  • Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem Biol. 2008 Jan;15(1):51-61. PMID: 18158259
  • Kang Y., Taldone T., Clement C.C., Fewell S.W., Aquirre J., Brodsky J.L., Chiosis G. (2008) Design of a fluorescene polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. Jul 1;18(13):3749-51. PMID 18515098
  • Liu L, Tang XH, Gudas LJ. Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet. Biochem Pharmacol. 2008 Jun 15;75(12):2316-24. PMID: 18455147
  • Tang XH, Vivero M, Gudas LJ. Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid. Exp Cell Res. 2008 Jan 1;314(1):38-51. PMID: 17727842
  • Deng X., Yin X., Allan R., Lu D.D., Maurer C.W., Haimovitz-Friedman A., Fuks A., Shaham S., Kolesnick R. (2008) Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science Oct 3;322(5898):110-5. PMID 18832646
  • Zhuang Y, Gudas LJ. Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression. Differentiation. Sep;76(7):760-71. PMID: 18177425
  • Zhang J., Zafrullan M., Yang X, Yin X, Zhang Z., Fuks Z., Kolesnick R. (2008) Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther Sep;7(9):1490-5. PMID 18719367
  • Lane M.A., Xu J., Wilen E.W., Sylvester R., Derguini F., Gudas L.J. LIF removal increases CRABPII transcripts in embryonicstam cells cultured in retinol or 4-oxoretinol. Mol Cell Endocrinol 2008 Jan 2:280(1-2):63-74.
  • Martinez-Ceballos E., Gudas L.J. Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons. J Neurosci Res 2008 Oct;86 (13):2809-19.
  • Cai K., Gudas L.J. Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acytranferase gene. Int J Biochem Biol 2009 Mar;41(3):546:53
  • Tavares T.S., Nanus D., Yang X.J., Gudas L.J. Gene macroarray analysis of human renal cell carcinoma: the effects of HDAC inhibition andretinoid treatment. Cancer Biol Ther 2008 Oct;7(10);1607-18.
  • Krishnakumar R., Gamble M.J., Frizzell K.M., Berrocal J.G., Kininis M., Kraus W.L. (2008)Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science Feb 8;319(5864):819-21. PMID 18258916
  • Brennan E.P., Tang X.H., Stewart-Akers A.M., Gudas L.J., Badylak S.F. Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells. J Tissue Eng Regen med 2008 Dec;2(8):491-8.

  2007

  • Angeles AR, Dorn DC, Kou CA, Moore MA, Danishefsky SJ. Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angew Chem Int Ed Engl. 2007;46(9):1451-4. PMID: 17387656
  • Upmacis R.K., Crabtree M.J., Deeb R.S., Shen H., Lane P.B., Benguigui L.E., Maeda N., Hajjar D.P., Gross S.S. (2007) Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol Nov;293(5):H2878-87. PMID 17766468
  • McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007 Jul;48(7):1180-9. PMID: 17607040
  • Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen. 2007 Jun;12(4):521-35. Epub 2007 Apr 13. PMID: 17435169
  • Beltrán C, Vacquier VD, Moy G, Chen Y, Buck J, Levin LR, Darszon A. Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1128-35. PMID: 17524362
  • Wacker D.A., Ruhl D.D., Balagamwala E.H., Hope K.M., Zhang T., Kraus W.L. (2007) The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transportation. Mol Cell Biol Nov;27(21):7475-85. PMID 17785446
  • Kininis M., Chen B.S., Diehl A.G., Isaacs G.D., Zhang T., Siepel A.C., Clark A.G., Kraus W.L. (2007) Genomic analyses of transcription factor binding histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol Jul;27(14):5090-104. PMID 17515612
  • McDevitt MR, Chattopadhyay D, Jaggi JS, Finn RD, Zanzonico PB, Villa C, Rey D, Mendenhall J, Batt CA, Njardarson JT, Scheinberg DA. PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE. 2007 Sep 19;2(9):e907.  PMID: 17878942
  • ENCODE Project Consortium, Birney E, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14;447(7146):799-816. PMID: 17571346
  • Jaggi JS, Carrasquillo JA, Seshan SV, Zanzonico P, Henke E, Nagel A, Schwartz J, Beattie B, Kappel BJ, Chattopadhyay D, Xiao J, Sgouros G, Larson SM, Scheinberg DA. Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor. J Clin Invest. 2007 Sep;117(9):2422-30. Erratum in: J Clin Invest. 2007 Nov;117(11):3593. PMID: 17717602
  • Singh Jaggi J, Henke E, Seshan SV, Kappel BJ, Chattopadhyay D, May C, McDevitt MR, Nolan D, Mittal V, Benezra R, Scheinberg DA. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PLoS ONE. 2007 Mar 7;2(3):e267. PMID: 17342201
  • Labitzke EM, Diani-Moore S, Rifkind AB. Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Arch Biochem Biophys. 2007 Dec 1;468(1):70-81. Epub 2007 Aug 25. PMID: 17959137
  • Garraway SM, Xu Q, Inturrisi CE. Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. J Pharmacol Exp Ther. 2007 Sep;322(3):982-8. Epub 2007 Jun 5. PMID: 17551091
  • Derakhshan B, Hao G, Gross SS. Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide. Cardiovasc Res. 2007 Jul 15;75(2):210-9. Epub 2007 May 3. PMID: 17524376
  • Hengst U, Jaffrey SR. Function and translational regulation of mRNA in developing axons. Semin Cell Dev Biol. 2007 Apr;18(2):209-15. Epub 2007 Feb 1. PMID: 17478114
  • Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23. PMID: 17977534
  • May RJ, Dao T, Pinilla-Ibarz J, Korontsvit T, Zakhaleva V, Zhang RH, Maslak P, Scheinberg DA. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4547-55. Erratum in: Clin Cancer Res. 2007 Sep 1;13(17):5226. PMID: 17671141
  • Morales A, Lee H, Goñi FM, Kolesnick R, Fernandez-Checa JC. Sphingolipids and cell death. Apoptosis. 2007 May;12(5):923-39. PMID: 17294080
  • Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, Isola J, Bendahl PO, Rosen N, Hibshoosh H, Ringnér M, Borg A, Parsons R. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9. Epub 2007 Apr 23. PMID: 17452630
  • Krauss IJ, Joyce JG, Finnefrock AC, Song HC, Dudkin VY, Geng X, Warren JD, Chastain M, Shiver JW, Danishefsky SJ. Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc. 2007 Sep 12;129(36):11042-4. Epub 2007 Aug 21. PMID: 17711286
  • Chen G, Wan Q, Tan Z, Kan C, Hua Z, Ranganathan K, Danishefsky SJ. Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl. 2007;46(39):7383-7. PMID: 17828726
  • Levi R, Seyedi N, Schaefer U, Estephan R, Mackins CJ, Tyler E, Silver RB. Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. Biochem Pharmacol. 2007 Apr 15;73(8):1146-56. Epub 2007 Jan 7. PMID: 17266940
  • Robzyk K, Oen H, Buchanan G, Butler LM, Tilley WD, Mandal AK, Rosen N, Caplan AJ. Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor. Mol Cell Endocrinol. 2007 Mar 30;268(1-2):67-74. Epub 2007 Feb 6. PMID: 17336451
  • Tsukano C, Siegel DR, Danishefsky SJ. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angew Chem Int Ed Engl. 2007;46(46):8840-4. PMID: 17935090
  • Scroggins BT, Robzyk K, Wang D, Marcu MG, Tsutsumi S, Beebe K, Cotter RJ, Felts S, Toft D, Karnitz L, Rosen N, Neckers L. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell. 2007 Jan 12;25(1):151-9. PMID: 17218278
  • Wan Q, Danishefsky SJ. Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew Chem Int Ed Engl. 2007;46(48):9248-52. PMID: 18046687
  • Owen HR, Elser M, Cheung E, Gersbach M, Kraus WL, Hottiger MO. MYBBP1a is a novel repressor of NF-kappaB. J Mol Biol. 2007 Feb 23;366(3):725-36. Epub 2006 Dec 15. PMID: 17196614
  • Cho J, Won K, Wu D, Soong Y, Liu S, Szeto HH, Hong MK. Potent mitochondria-targeted peptides reduce myocardial infarction in rats. Coron Artery Dis. 2007 May;18(3):215-20. PMID: 17429296
  • Shang S, Iwadare H, Macks DE, Ambrosini LM, Tan DS. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Org Lett. 2007 May 10;9(10):1895-8. Epub 2007 Apr 17. PMID: 17439132
  • Tang XH, Suh MJ, Li R, Gudas LJ. Cell proliferation inhibition and alterations in retinol esterification induced by phytanic acid and docosahexaenoic acid. J Lipid Res. 2007 Jan;48(1):165-76. Epub 2006 Oct 26. PMID: 17068359
  • Krauss IJ, Mandal M, Danishefsky SJ. Total synthesis of (+)-isomigrastatin. Angew Chem Int Ed Engl. 2007;46(29):5576-9. PMID: 17583888
  • Boorjian SA, Milowsky MI, Kaplan J, Albert M, Cobham MV, Coll DM, Mongan NP, Shelton G, Petrylak D, Gudas LJ, Nanus DM. Phase 1/2 clinical trial of interferon alpha2b and weekly liposome-encapsulated all-trans retinoic acid in patients with advanced renal cell carcinoma. J Immunother. 2007 Sep;30(6):655-62. PMID: 17667529
  • Thomas DA, Stauffer C, Zhao K, Yang H, Sharma VK, Szeto HH, Suthanthiran M. Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function. J Am Soc Nephrol. 2007 Jan;18(1):213-22. Epub 2006 Dec 6. PMID: 17151329
  • Mongan NP, Gudas LJ. Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation. 2007 Nov;75(9):853-70. Epub 2007 Jul 18. PMID: 17634071
  • Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. J Biol Chem. 2007 Aug 10;282(32):23639-44. Epub 2007 Jun 7. PMID: 17556361

  2006

  • Antczak C, Jaggi JS, LeFave CV, Curcio MJ, McDevitt MR, Scheinberg DA. Influence of the linker on the biodistribution and catabolism of actinium-225 self-immolative tumor-targeted isotope generators. Bioconjug Chem. 2006 Nov-Dec;17(6):1551-60. PMID: 17105236
  • Chen J, Chen G, Wu B, Wan Q, Tan Z, Hua Z, Danishefsky SJ. Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Lett. 2006 Nov 13;47(46):8013-8016. PMID: 17426819
  • Gomez-Nunez M, Pinilla-Ibarz J, Dao T, May RJ, Pao M, Jaggi JS, Scheinberg DA. Peptide binding motif predictive algorithms correspond with experimental binding of leukemia vaccine candidate peptides to HLA-A*0201 molecules. Leuk Res. 2006 Oct;30(10):1293-8. Epub 2006 Mar 14. PMID: 16533527
  • Hao G, Gross SS. Electrospray tandem mass spectrometry analysis of S- and N-nitrosopeptides: facile loss of NO and radical-induced fragmentation. J Am Soc Mass Spectrom. 2006 Dec;17(12):1725-30. Epub 2006 Sep 6. PMID: 16952458
  • Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PMID: 16597739
  • Deeb RS, Hao G, Gross SS, Lainé M, Qiu JH, Resnick B, Barbar EJ, Hajjar DP, Upmacis RK. Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. J Lipid Res. 2006 May;47(5):898-911. Epub 2006 Feb 9. PMID: 16470026
  • Hao G, Derakhshan B, Shi L, Campagne F, Gross SS. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1012-7. Epub 2006 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242. PMID: 16418269
  • Mackins CJ, Kano S, Seyedi N, Schäfer U, Reid AC, Machida T, Silver RB, Levi R. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest. 2006 Apr;116(4):1063-70. PMID: 16585966
  • Pinilla-Ibarz J, May RJ, Korontsvit T, Gomez M, Kappel B, Zakhaleva V, Zhang RH, Scheinberg DA. Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein. Leukemia. 2006 Nov;20(11):2025-33. Epub 2006 Aug 31. PMID: 16990779
  • Suh MJ, Tang XH, Gudas LJ. Structure elucidation of retinoids in biological samples using postsource decay laser desorption/ionization mass spectrometry after high-performance liquid chromatography separation. Anal Chem. 2006 Aug 15;78(16):5719-28. PMID: 16906716
  • Rosen N, She QB. AKT and cancer--is it all mTOR? Cancer Cell. 2006 Oct;10(4):254-6. PMID: 17045203
  • Liu H, Siegel DR, Danishefsky SJ. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Org Lett. 2006 Feb 2;8(3):423-5. PMID: 16435850
  • Chen G, Warren JD, Chen J, Wu B, Wan Q, Danishefsky SJ. Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. J Am Chem Soc. 2006 Jun 14;128(23):7460-2. PMID: 16756298
  • Wu B, Chen J, Warren JD, Chen G, Hua Z, Danishefsky SJ. Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angew Chem Int Ed Engl. 2006 Jun 19;45(25):4116-25. PMID: 16710874
  • Siegel DR, Danishefsky SJ. Total synthesis of garsubellin A. J Am Chem Soc. 2006 Feb 1;128(4):1048-9. PMID: 16433500
  • Wan Q, Chen J, Chen G, Danishefsky SJ. A potentially valuable advance in the synthesis of carbohydrate-based anticancer vaccines through extended cycloaddition chemistry. J Org Chem. 2006 Oct 13;71(21):8244-9. PMID: 17025318
  • Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, Spassova MK, Keding SJ, Allen J, Ouerfelli O, Wilson RM, Danishefsky SJ. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc. 2006 Mar 1;128(8):2715-25. PMID: 16492059
  • Diani-Moore S, Labitzke E, Brown R, Garvin A, Wong L, Rifkind AB. Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo. Toxicol Sci. 2006 Mar;90(1):96-110. Epub 2005 Dec 5. PMID: 16330490
  • Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):57-62. Epub 2005 Dec 21. PMID: 16371460
  • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006 Feb 1;66(3):1500-8. PMID: 16452206
  • Zhang Y, Pan YX, Kolesnikov Y, Pasternak GW. Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system. Brain Res. 2006 Jul 12;1099(1):33-43. Epub 2006 Jun 21. PMID: 16793025
  • Raman JD, Mongan NP, Liu L, Tickoo SK, Nanus DM, Scherr DS, Gudas LJ. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Carcinogenesis. 2006 Mar;27(3):499-507. Epub 2005 Dec 12. PMID: 16344273
  • Mongan NP, Martin KM, Gudas LJ. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. Mol Carcinog. 2006 Dec;45(12):887-900. PMID: 16865673
  • Carcache DA, Cho YS, Hua Z, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures. J Am Chem Soc. 2006 Jan 25;128(3):1016-22. PMID: 16417394
  • Lambert TH, Danishefsky SJ. Total synthesis of UCS1025A. J Am Chem Soc. 2006 Jan 18;128(2):426-7. PMID: 16402826
  • Deeb RS, Shen H, Gamss C, Gavrilova T, Summers BD, Kraemer R, Hao G, Gross SS, Lainé M, Maeda N, Hajjar DP, Upmacis RK. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Am J Pathol. 2006 Jan;168(1):349-62. PMID: 16400036
  • Wu KY, Zippin JH, Huron DR, Kamenetsky M, Hengst U, Buck J, Levin LR, Jaffrey SR. Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci. 2006 Oct;9(10):1257-64. Epub 2006 Sep 10. PMID: 16964251
  • Hengst U, Cox LJ, Macosko EZ, Jaffrey SR. Functional and selective RNA interference in developing axons and growth cones. J Neurosci. 2006 May 24;26(21):5727-32.  PMID: 16723529
  • Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J. 2006 Oct 4;25(19):4490-502. Epub 2006 Sep 21. PMID: 16990801
  • Diani-Moore S, Papachristou F, Labitzke E, Rifkind AB. Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab Dispos. 2006 Aug;34(8):1376-85. Epub 2006 May 19. PMID: 16714371
  • Sheren-Manoff M., Shin S.J., Su D., Bok D., Rando R.R., Gudas L.J. Reduced lecithin: retinol acytransferase expression in human breas cancer. Int J Oncol 2006 Nov;29(5);1193-9.
  • Kong K.Y., Marcus A. I., Hong J.Y., Giannakakou P., Wanf M.D. (2006) Automatic microtubule tracking for QD-based in vivo cell imaging and drug efficacy study. Conf Proc IEEE Eng Med Biol Soc 2006;1:3321-4. PMID 17947021

  2005

  • Dao T, Gomez-Nunez M, Antczak C, Kappel B, Jaggi JS, Korontsvit T, Zakhaleva V, Scheinberg DA. Natural killer cells license dendritic cell cross-presentation of B lymphoma cell--associated antigens. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8763-72. PMID: 16361564
  • Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS, Levin LR, Williams CJ, Buck J, Moss SB. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59. PMID: 16054031
  • Cheung E, Acevedo ML, Cole PA, Kraus WL. Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):559-64. Epub 2005 Jan 10. PMID: 15642950
  • Wu KY, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR. Local translation of RhoA regulates growth cone collapse. Nature. 2005 Aug 18;436(7053):1020-4.  PMID: 16107849
  • He XG, Gerona-Navarro G, Jaffrey SR. Ligand discovery using small molecule microarrays. J Pharmacol Exp Ther. 2005 Apr;313(1):1-7. Epub 2004 Nov 10. PMID: 15537823
  • Mongan NP, Gudas LJ. Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells. Mol Cancer Ther. 2005 Mar;4(3):477-86. PMID: 15767557
  • Ferreras JA, Ryu JS, Di Lello F, Tan DS, Quadri LE. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol. 2005 Jun;1(1):29-32. Epub 2005 May 24. PMID: 16407990
  • Boorjian S, Scherr DS, Mongan NP, Zhuang Y, Nanus DM, Gudas LJ. Retinoid receptor mRNA expression profiles in human bladder cancer specimens. Int J Oncol. 2005 Apr;26(4):1041-8. PMID: 15754000
  • Levin E, Premkumar A, Veenman L, Kugler W, Leschiner S, Spanier I, Weisinger G, Lakomek M, Weizman A, Snyder SH, Pasternak GW, Gavish M. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Biochemistry. 2005 Jul 26;44(29):9924-35. PMID: 16026165
  • Hua Z, Carcache DA, Tian Y, Li YM, Danishefsky SJ. The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. J Org Chem. 2005 Nov 25;70(24):9849-56. PMID: 16292815
  • Mandal M, Yun H, Dudley GB, Lin S, Tan DS, Danishefsky SJ. Total synthesis of guanacastepene a: a route to enantiomeric control. J Org Chem. 2005 Dec 23;70(26):10619-37. PMID: 16355979
  • Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med. 2005 May;11(5):484-90. Epub 2005 May 1. Erratum in: Nat Med. 2006 Feb;12(2):253. PMID: 15864314
  • Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R. Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem. 2005 Jul 15;280(28):26425-34. Epub 2005 Apr 22. PMID: 15849201
  • Endo A, Danishefsky SJ. Total synthesis of salinosporamide A. J Am Chem Soc. 2005 Jun 15;127(23):8298-9. PMID: 15941259
  • Palomba ML, Roberts WK, Dao T, Manukian G, Guevara-Patiño JA, Wolchok JD, Scheinberg DA, Houghton AN. CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma. Clin Cancer Res. 2005 Jan 1;11(1):370-9. PMID: 15671568
  • Diblasi CM, Macks DE, Tan DS. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Org Lett. 2005 Apr 28;7(9):1777-80. PMID: 15844904
  • Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8570-6. PMID: 16361539
  • Seyedi N, Mackins CJ, Machida T, Reid AC, Silver RB, Levi R. Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium. J Pharmacol Exp Ther. 2005 Jan;312(1):272-80. Epub 2004 Aug 11. PMID: 15306634
  • She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell. 2005 Oct;8(4):287-97. PMID: 16226704
  • Cho YS, Wan Q, Danishefsky SJ. Organic synthesis in pursuit of immunology: large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine. Bioorg Med Chem. 2005 Sep 1;13(17):5259-66. PMID: 16006132
  • Zhao K, Luo G, Giannelli S, Szeto HH. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochem Pharmacol. 2005 Dec 5;70(12):1796-806. Epub 2005 Oct 10. PMID: 16216225
  • Szeto HH, Schiller PW, Zhao K, Luo G. Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides. FASEB J. 2005 Jan;19(1):118-20. Epub 2004 Oct 15. PMID: 15489247
  • Ouerfelli O, Warren JD, Wilson RM, Danishefsky SJ. Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Rev Vaccines. 2005 Oct;4(5):677-85. PMID: 16221069
  • Waters SP, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. J Am Chem Soc. 2005 Oct 5;127(39):13514-5. PMID: 16190712

  2004

  • Reid AC, Mackins CJ, Seyedi N, Levi R, Silver RB. Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1448-54. Epub 2003 Dec 18. PMID: 14684374
  • Warren JD, Miller JS, Keding SJ, Danishefsky SJ. Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc. 2004 Jun 2;126(21):6576-8. PMID: 15161285
  • Hao G, Xie L, Gross SS. Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. J Biol Chem. 2004 Aug 27;279(35):36192-200. Epub 2004 Jun 10. PMID: 15192091
  • Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cardon-Cardo C, Nimer S, Fuks Z, Kolesnick R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res. 2004 Nov 15;64(22):8285-91. PMID: 15548696
  • Dudkin VY, Orlova M, Geng X, Mandal M, Olson WC, Danishefsky SJ. Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. J Am Chem Soc. 2004 Aug 11;126(31):9560-2. PMID: 15291558
  • Boorjian S, Ugras S, Mongan NP, Gudas LJ, You X, Tickoo SK, Scherr DS. Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology. 2004 Aug;64(2):383-8. PMID: 15302512
  • Zhao K, Zhao GM, Wu D, Soong Y, Birk AV, Schiller PW, Szeto HH. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem. 2004 Aug 13;279(33):34682-90. Epub 2004 Jun 2. PMID: 15178689
  • Boorjian S, Tickoo SK, Mongan NP, Yu H, Bok D, Rando RR, Nanus DM, Scherr DS, Gudas LJ. Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Clin Cancer Res. 2004 May 15;10(10):3429-37. PMID: 15161698
  • Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. Epub 2004 Nov 24. PMID: 15563588
  • Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. J Org Chem. 2004 Oct 15;69(21):7344-7. PMID: 15471490
  • Geng X, Dudkin VY, Mandal M, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. Angew Chem Int Ed Engl. 2004 May 3;43(19):2562-5. PMID: 15127453
  • Kolesnick R, Xing HR. Inflammatory bowel disease reveals the kinase activity of KSR1. J Clin Invest. 2004 Nov;114(9):1233-7. PMID: 15520853
  • Xing HR, Campodonico L, Kolesnick R. The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. J Biol Chem. 2004 Jun 18;279(25):26210-4. Epub 2004 Apr 13. PMID: 15084597
  • Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R. Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet. 2004 Aug;36(8):906-12. Epub 2004 Jul 25. PMID: 15273685
  • Mandal M, Dudkin VY, Geng X, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments. Angew Chem Int Ed Engl. 2004 May 3;43(19):2557-61. PMID: 15127452
  • Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):301-13. PMID: 14734483
  • Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem. 2004 Nov 19;279(47):48615-9. Epub 2004 Sep 29. PMID: 15456788

  2003

  • Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochem Biophys Res Commun. 2003 Dec 12;312(2):309-15. PMID: 14637138
  • Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5;278(49):49523-9. Epub 2003 Sep 25. PMID: 14512417
  • McGarry RC, Barron YD, Carvalho MF, Hill JE, Gold D, Cheung E, Kraus WL, Lazarowitz SG. A novel Arabidopsis acetyltransferase interacts with the geminivirus movement protein NSP. Plant Cell. 2003 Jul;15(7):1605-18.  PMID: 12837950
  • Cheung E, Schwabish MA, Kraus WL. Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta. EMBO J. 2003 Feb 3;22(3):600-11. PMID: 12554660
  • Koyama M, Seyedi N, Fung-Leung WP, Lovenberg TW, Levi R. Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors. Mol Pharmacol. 2003 Feb;63(2):378-82. PMID: 12527809
  • Xing HR, Cordon-Cardo C, Deng X, Tong W, Campodonico L, Fuks Z, Kolesnick R. Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med. 2003 Oct;9(10):1266-8. Epub 2003 Sep 7. PMID: 12960962
  • Lozano J, Xing R, Cai Z, Jensen HL, Trempus C, Mark W, Cannon R, Kolesnick R. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 2003 Jul 15;63(14):4232-8. PMID: 12874031
  • Zhao K, Luo G, Zhao GM, Schiller PW, Szeto HH. Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide. J Pharmacol Exp Ther. 2003 Jan;304(1):425-32. PMID: 12490619
  • Sun XC, Zhai CB, Cui M, Chen Y, Levin LR, Buck J, Bonanno JA. HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol. 2003 May;284(5):C1114-22. Epub 2003 Jan 8. PMID: 12519749
  • Maj JG, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks Z. Microvascular function regulates intestinal crypt response to radiation. Cancer Res. 2003 Aug 1;63(15):4338-41. PMID: 12907601
  • Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J. Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J. 2003 Jan;17(1):82-4. Epub 2002 Nov 15. PMID: 12475901
  • Crabtree M, Hao G, Gross SS. Detection of cysteine S-nitrosylation and tyrosine 3-nitration in kidney proteins. Methods Mol Med. 2003;86:373-84. PMID: 12886782
  • Zhuang Y, Faria TN, Chambon P, Gudas LJ. Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. Mol Cancer Res. 2003 Jun;1(8):619-30. PMID: 12805409
  • Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003 May 16;300(5622):1155-9. PMID: 12750523

  2002

  • Cheung E, Zarifyan AS, Kraus WL. Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation. Mol Cell Biol. 2002 Apr;22(8):2463-71. PMID: 11909941
  • Wood E, Johan Broekman M, Kirley TL, Diani-Moore S, Tickner M, Drosopoulos JH, Islam N, Park JI, Marcus AJ, Rifkind AB. Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 2002 Nov 1;407(1):49-62. PMID: 12392715
  • Levi R, Silver RB, Mackins CJ, Seyedi N, Koyama M. Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release. Int Immunopharmacol. 2002 Dec;2(13-14):1965-73. PMID: 12489810
  • Seyedi N, Koyama M, Mackins CJ, Levi R. Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. J Pharmacol Exp Ther. 2002 Aug;302(2):539-44. PMID: 12130713
  • Silver RB, Poonwasi KS, Seyedi N, Wilson SJ, Lovenberg TW, Levi R. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):501-6. Epub 2001 Dec 18. PMID: 11752397

  2001

  • Xing HR, Kolesnick R. Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J Biol Chem. 2001 Mar 30;276(13):9733-41. Epub 2000 Dec 27. PMID: 11134016
  • Lane P, Hao G, Gross SS. S-nitrosylation is emerging as a specific and fundamental posttranslational protein modification: head-to-head comparison with O-phosphorylation. Sci STKE. 2001 Jun 12;2001(86):RE1. PMID: 11752656
  • Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner MO, Kolesnick RN. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J. 2001 Sep 17;20(18):5114-28. PMID: 11566876

  2000

  • Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 2000 Jul 28;289(5479):625-8.  PMID: 1091562
  • Lukashok SA, Tarassishin L, Li Y, Horwitz MS. An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase. J Virol. 2000 May;74(10):4705-9. PMID: 10775608
  • Levi R, Maruyama R, Smith NC, Seyedi N. Is the lower mortality in patients treated with aspirin and angiotensin-converting enzyme inhibitors due to decreased norepinephrine release? J Am Coll Cardiol. 2000 Mar 1;35(3):817-9. PMID: 10716490
  • Xing HR, Lozano J, Kolesnick R. Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. J Biol Chem. 2000 Jun 9;275(23):17276-80. PMID: 10764733