Selected Publications

2018 (Updated 10/2018)

• Rafiq S, Yeku OO, Jackson HJ, Purdon TJ, van Leeuwen DG, Drakes DJSong M, Miele MM, Li Z, Wang P, Yan S, Xiang J, Ma X, Seshan VE, Hendrickson RC, Liu C, Brentjens RJ. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Nat Biotechnol. 2018 Oct;36(9):847-856. doi: 10.1038/nbt.4195. Epub 2018 Aug 13. PMID: 30102295 PMCID: PMC6126939 [Available on 2019-02-13] DOI: 10.1038/nbt.4195

• Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ. CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation. J Mol Biol. 2018 Aug 25. pii: S0022-2836(18)30686-7. doi: 10.1016/j.jmb.2018.08.014. PMID:30153436 DOI:10.1016/j.jmb.2018.08.014

• Pratt EC, Shaffer TM, Zhang Q, Drain CM, Grimm J. Nanoparticles as multimodal photon transducers of ionizing radiation. Nat Nanotechnol. 2018 Mar 26. doi: 10.1038/s41565-018-0086-2. PMID: 29581551 DOI: 10.1038/s41565-018-0086-2 .

2017 (Updated 10/2017)

• Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15. PubMed PMID: 28619981; PubMed Central PMCID: PMC5581705.

• Scheinberg DA, Grimm J, Heller DA, Stater EP, Bradbury M, McDevitt MR. Advances in the clinical translation of nanotechnology. Curr Opin Biotechnol. 2017 Aug;46:66-73. doi: 10.1016/j.copbio.2017.01.002. Epub 2017 Feb 7. PMID: 28187340 PMCID: PMC5544552

• Stawowczyk M, Wellenstein MD, Lee SB, Yomtoubian S, Durrans A, Choi H, Narula N, Altorki NK, Gao D, Mittal V. Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia. 2017 Feb;19(2):55-64. doi:10.1016/j.neo.2016.11.005. Epub 2016 Dec 23. PMID: 28013056 PMCID: PMC5198728

• Walsh LA, Alvarez MJ, Sabio EY, Reyngold M, Makarov V, Mukherjee S, Lee KW, Desrichard A, Turcan S, Dalin MG, Rajasekhar VK, Chen S, Vahdat LT, Califano A, Chan TA. An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. Cell Rep. 2017 Aug 15;20(7):1623-1640. doi: 10.1016/j.celrep.2017.07.052. PMID:28813674.

• Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Beguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG. Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma. Sci Transl Med. 2017 Jun 28;9(396). pii: eaak9969. doi: 10.1126/scitranslmed.aak9969. PMID:28659443 PMCID:PMC5559734.

• Song W, Filonov GS, Kim H, Hirsch M, Li X, Moon JD, Jaffrey SR. Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nat Chem Biol. 2017 Sep 25. doi: 10.1038/nchembio.2477. PMID:28945233

• Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC. Daily Rhythm in Plasma N-acetyltryptamine. J Biol Rhythms. 2017 Jun;32(3):195-211. doi: 10.1177/0748730417700458. Epub 2017 May 3. PMID:28466676.

2016

• Dao T, Korontsvit T, Zakhaleva V, Jarvis C, Mondello P Oh C, Scheinberg DA. An immunogenic WT1-derived peptide that induces T cell response in the context of HLA-A*02:01 and HLA-A*24:02 molecules. Oncoimmunology. 2016 Dec 7;6(2):e1252895. doi: 10.1080/2162402X.2016.1252895. eCollection 2017. PMID:28344864 PMCID:PMC5353933

• Gold B, Roberts J, Ling Y, Lopez Quezada L, Glasheen J, Somersan-Karakaya S, Warrier T, Ballinger E, Nathan C. Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria. J Vis Exp. 2016 Dec 14;(118). doi: 10.3791/54690. PMID: 28060290 PMCID: PMC5226417 DOI 10.3791/54690

• Culjkovic-Kraljacic B, Fernando TM, Marullo R, Calvo-Vidal N, Verma A, Yang S, Tabbo F, Gaudiano M, Zahreddine H, Goldstein RL, Patel J, Taldone T, Chiosis G, Ladetto M, Ghione P, Machiorlatti R, Elemento O, Inghirami G, Melnick A, Borden KL, Cerchietti L. Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas. Blood. 2016 Feb 18;127(7):858-68. doi: 10.1182/blood-2015-05-645069. Epub 2015 Nov 24. PMID:26603836.

• Minton DR, Fu L, Mongan NP, Shevchuk MM, Nanus DM, Gudas LJ. Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2016 Jan 18. [Epub ahead of print] PMID:26783287.

• Ataie N, Xiang J, Cheng N, Brea EJ, Lu W, Scheinberg DA, Liu C, Ng HL. Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Mar 23. doi: 10.1002/wnan.1402. [Epub ahead of print] PMID:27006133.

• Pratt EC, Shaffer TM, Grimm J. Nanoparticles and radiotracers: advances toward radionanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Mar 23. doi: 10.1002/wnan.1402. [Epub ahead of print] PMID:27006133.

• Roxbury D, Jena PV, Shamay Y, Horoszko CP, Heller DA. Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation. ACS Nano. 2016 Jan 26;10(1):499-506. doi: 10.1021/acsnano.5b05438. Epub 2015 Dec 11. PMID:26654246.

• Paresi CJ, Liu Q, Li YM. Benzimidazole covalent probes and the gastric H+/K+-ATPase as a model system for protein labeling in a copper-free setting. Mol Biosyst. 2016 Mar 8. PMID:26952080 .

2015

• Alam NM, Mills WC, Wong AA, Douglas RM, Szeto HH, Prusky GT. A mitochondrial therapeutic reverses visual decline in mouse models of diabetes. Dis Model Mech. 2015 Jul 1;8(7):701-10. doi: 10.1242/dmm.020248. Epub 2015 Apr 23. PMID:26035391

• Williams RM, Shah J, Ng BD, Minton DR, Gudas LJ, Park CY, Heller DA. Mesoscale nanoparticles selectively target the renal proximal tubule epithelium. Nano Lett. 2015 Apr 8;15(4):2358-64. doi: 10.1021/nl504610d. Epub 2015 Mar 26. PMID:25811353

• Fu L, Minton DR, Zhang T, Nanus DM, Gudas LJ. Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome. Mol Cancer Res. 2015 May;13(5):870-8. doi: 10.1158/1541-7786.MCR-14-0423. Epub 2015 Feb 25. PMID:25715653

• Minton DR, Fu L, Chen Q, Robinson BD, Gross SS, Nanus DM, Gudas LJ. Analyses of the transcriptome and metabolome demonstrate that HIF1a mediates altered tumor metabolism in clear cell renal cell carcinoma. PLoS One. 2015 Apr 1;10(4):e0120649. doi: 10.1371/journal.pone.0120649. eCollection 2015. PMID:25830305

• Mets E, Van der Meulen J, Van Peer G, Boice M, Mestdagh P, Van de Walle I, Lammens T, Goossens S, De Moerloose B, Benoit Y, Van Roy N, Clappier E, Poppe B, Vandesompele J, Wendel HG, Taghon T, Rondou P, Soulier J, Van Vlierberghe P, Speleman F. MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. Leukemia. 2015 Apr;29(4):798-806. doi: 10.1038/leu.2014.276. Epub 2014 Sep 18. PMID:25231743

• Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan CF. E1 of a-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5834-43. doi: 10.1073/pnas.1510932112. Epub 2015 Oct 1. PMID:26430237

• Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinb). 2015 Dec;95(6):689-94. doi: 10.1016/j.tube.2015.08.009. Epub 2015 Oct 19. PMID:26547230

• Dubrovsky L, Dao T, Gejman RS, Brea EJ, Chang AY, Oh CY, Casey E, Pankov D, Scheinberg DA. T cell receptor mimic antibodies for cancer therapy. Oncoimmunology. 2015 Jun 1;5(1):e1049803. PMID:26942058

• Gold B, Roberts J, Ling Y, Quezada LL, Glasheen J Ballinger E, Somersan-Karakaya S, Warrier T, Warren JD, Nathan C. Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Oct;59(10):6521-38. doi: 10.1128/AAC.00803-15. Epub 2015 Aug 3. PMID:26239979.

• Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P. Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer Discov. 2015 Mar;5(3):304-15. doi: 10.1158/2159-8290.CD-14-0985. Epub 2015 Jan 8. PMID: 25572173

• Gertsik N, Chiu D,Li YM. Complex regulation of y-secretase: from obligatory to modulatory subunits. Front Aging Neurosci. 2015 Jan 6;6:342. doi: 10.3389/fnagi.2014.00342. eCollection 2014. Review.

• Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ. Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Biochemistry. 2015 Oct 27;54(42):6514-24. doi: 10.1021/acs.biochem.5b00966. Epub 2015 Oct 15. PMID:26394156

• Culley KL1, Dragomir CL, Chang J, Wondimu EB, Coico J, Plumb DA, Otero M, Goldring MB. Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus.Methods Mol Biol. 2015;1226:143-73. doi: 10.1007/978-1-4939-1619-1_12.

2014

• Gudas LJ, Fu L, Minton DR, Mongan NP, Nanus DM. The role of HIF1a in renal cell carcinoma tumorigenesis. J Mol Med (Berl). 2014 Aug;92(8):825-36. doi: 10.1007/s00109-014-1180-z. Epub 2014 Jun 12. PMID:24916472

• Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J, Toth M. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nat Neurosci. 2014 Jan;17(1):97-105. doi: 10.1038/nn.3596. Epub 2013 Dec 1. PMID:24292233

• Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P1, Benoit Y, De Moerloose B, Van Roy N, Poppe B, Vandesompele J, Wendel HG, Van Vlierberghe P, Speleman F, Rondou P. MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. Haematologica. 2014 Aug;99(8):1326-33. doi: 10.3324/haematol.2013.099515. Epub 2014 Jun 3. PMID:24895337

• Sanghvi VR, Mavrakis KJ, Van der Meulen J, Boice M, Wolfe AL, Carty M, Mohan P, Rondou P, Socci ND, Benoit Y, Taghon T, Van Vlierberghe P, Leslie CS, Speleman F, Wendel HG. Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia. Sci Signal. 2014 Nov 18;7(352):ra111. doi: 10.1126/scisignal.2005500. PMID:25406379

• Maguire WF, McDevitt MR, Smith-Jones PM, Scheinberg DA. Efficient 1-step radiolabeling of monoclonal antibodies to high specific activity with 225Ac for a-particle radioimmunotherapy of cancer. J Nucl Med. 2014 Sep;55(9):1492-8. doi: 10.2967/jnumed.114.138347. Epub 2014 Jun 30. PMID:24982438

• Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of Y-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21;8(4):1077-92. doi: 10.1016/j.celrep.2014.07.028. Epub 2014 Aug 14. PMID:25131208

• Mulvey JJ, Feinberg EN, Alidori S, McDevitt MR, Heller DA, Scheinberg DA. Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes. Int J Nanomedicine. 2014 Sep 4;9:4245-55. doi: 10.2147/IJN.S66050. eCollection 2014. PMID:25228803

• Dubrovsky L, Pankov D, Brea EJ, Dao T, Scott A, Yan S, O'Reilly RJ, Liu C, Scheinberg DA. A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias. Elife. 2014 May 19;3:e02283. doi: 10.7554/eLife.02283. PMID: 24842876

• Verdon G, Oh S, Serio RN, Boudker O. Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. Elife. 2014 May 19;3:e02283. doi: 10.7554/eLife.02283. PMID: 24842876

• Vivanco I, Chen ZC, Tanos B, Oldrini B, Hsieh WY, Yannuzzi N, Campos C, Mellinghoff IK. A kinase-independent function of AKT promotes cancer cell survival. Elife. 2014 Dec 31;3. doi: 10.7554/eLife.03751. PMID: 25551293

• Peng X, Thierry-Mieg J, Thierry-Mieg D, Nishida A, Pipes L, Bozinoski M, Thomas MJ, Kelly S, Weiss JM, Raveendran M, Muzny D, Gibbs RA, Rogers J, Schroth GP, Katze MG, Mason CE. Tissue-specific transcriptome sequencing analysis expands the non-human primate reference transcriptome resource (NHPRTR). Nucleic Acids Res. 2015 Jan;43(Database issue):D737-42. doi: 10.1093/nar/gku1110. Epub 2014 Nov 11.

• Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of y-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21;8(4):1077-92. doi: 10.1016/j.celrep.2014.07.028. Epub 2014 Aug 14.

• Laird E, Bozinoski M, Liu B, Zupan B, , Klein S, Gleason G, , Gal Toth J, Toth M, Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nat Neurosci. 2014 Jan;17(1):97-105. doi: 10.1038/nn.3596. Epub 2013 Dec 1.

• Paresi CJ, Liu Q, Li YM. Chemical synthesis of the ATAD2 bromodomain.. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2891-6. doi: 10.1073/pnas.1400556111. Epub 2014 Feb 10.PMID:24516155

2013

• Birk AV, Liu S, Soong Y, Mills W, Singh P, Warren JD, Seshan SV, Pardee JD, Szeto HH. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013 Jul;24(8):1250-61. doi: 10.1681/ASN.2012121216. Epub 2013 Jul 11. PMID:23813215

• Maksymiuk C, Balakrishnan A, Wu YT, Wong CH, Masquelin T, Hipskind P, Lima CD, Nathan C . Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 2013 Dec 23;52(51):9375-84. doi: 10.1021/bi401077f. Epub 2013 Nov 26. PMID:24251446

• Scheinberg DA, McDevitt MR, Dao T, Mulvey JJ, Feinberg E, Alidori S. Carbon nanotubes as vaccine scaffolds. Adv Drug Deliv Rev. 2013 Dec;65(15):2016-22. doi: 10.1016/j.addr.2013.07.013. Epub 2013 Jul 27. PMID:23899863.

• Mulvey JJ, Villa CH, McDevitt MR, Escorcia FE, Casey E, Scheinberg DA. Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol. 2013 Oct;8(10):763-71. doi: 10.1038/nnano.2013.190. Epub 2013 Sep 29. PMID:24077028.

• Rosenfeld GE,Mercer EJ, Mason CE, Evans T. Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Dev Biol. 2013 Sep 15;381(2):389-400. doi: 10.1016/j.ydbio.2013.06.025. Epub 2013 Jul 11. PMID:23850773.

• Jeng PS, Cheng EH. Cancer therapeutics: Pulling the plug on BCL-X(L). Nat Chem Biol. 2013 Jun;9(6):351-2. doi: 10.1038/nchembio.1256. PMID:23689630.

2012

• Pipes L, Li S, Bozinoski M, Palermo R, Peng X, Blood P, Kelly S, Weiss JM, Thierry-Mieg J, Thierry-Mieg D, Zumbo P, Chen R, Schroth GP, Mason CE, Katze MG. The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics. Nucleic Acids Res. 2013 Jan;41(Database issue):D906-14. doi: 10.1093/nar/gks1268. Epub 2012 Nov 29. PMID: 23203872 .

• Wurst JM, Verano AL, Tan DS. Stereoselective synthesis of acortatarins A and B. Org Lett. 2012 Sep 7;14(17):4442-5. doi: 10.1021/ol3019456. Epub 2012 Aug 27.

• Tseng HM, Shum D, Bhinder B, Escobar S, Veomett NJ, Tomkinson AE, Gin DY, Djaballah H, Scheinberg DA. A high-throughput scintillation proximity-based assay for human DNA ligase IV. Assay Drug Dev Technol. 2012 Jun;10(3):235-49. doi: 10.1089/adt.2011.0404.
• Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One. 2012;7(8):e42756. doi: 10.1371/journal.pone.0042756.
• Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. FASEB J. 2012 Aug;26(8):3252-9. doi: 10.1096/fj.12-206110.
• Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, Deangelis LM, Nimer SD, Holland EC, Squatrito M. MEF Promotes Stemness in the Pathogenesis of Gliomas. Cell Stem Cell. 2012 Dec 7;11(6):836-844. doi: 10.1016/j.stem.2012.09.012.
• Wang R, Islam K, Liu Y, Zheng W, Tang H, Lailler N, Blum G, Deng H, Luo M. Profiling Genome-wide Chromatin Methylation with Engi-neered Posttranslation Apparatus within Living Cells.J Am Chem Soc. 2012 Dec 17. [Epub ahead of print]
• Xu H, Menendez S, Schlegelberger B, Bae N, Aplan PD, Göhring G, Deblasio TR, Nimer SD. Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model. Blood. 2012 Oct 11;120(15):3089-97. doi: 10.1182/blood-2012-01-405332.
• Asai T, Liu Y, Di Giandomenico S, Bae N, Ndiaye-Lobry D, Deblasio A, Menendez S, Antipin Y, Reva B, Wevrick R, Nimer SD. Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells. Blood. 2012 Aug 23;120(8):1601-12. doi: 10.1182/blood-2011-11-393983.
• Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18;51(37):7209-11. doi: 10.1021/bi301137h.
• Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, Kubek S, Oldrini B, Chheda MG, Yannuzzi N, Tao H, Zhu S, Iwanami A, Kuga D, Dang J, Pedraza A, Brennan CW, Heguy A, Liau LM, Lieberman F, Yung WK, Gilbert MR, Reardon DA, Drappatz J, Wen PY, Lamborn KR, Chang SM, Prados MD, Fine HA, Horvath S, Wu N, Lassman AB, DeAngelis LM, Yong WH, Kuhn JG, Mischel PS, Mehta MP, Cloughesy TF, Mellinghoff IK. Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov. 2012 May;2(5):458-71. doi: 10.1158/2159-8290.CD-11-0284.
• Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860.
• Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012 Feb 15;483(7390):479-83. doi: 10.1038/nature10866.
• Haro KJ, Sheth A, Scheinberg DA. Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells. PLoS One. 2012;7(11):e48841. doi: 10.1371/journal.pone.0048841.
• Wurst JM, Verano AL, Tan DS. Stereoselective synthesis of acortatarins A and B. Org Lett. 2012 Sep 7;14(17):4442-5. doi: 10.1021/ol3019456.
• Islam K, Bothwell I, Chen Y, Sengelaub C, Wang R, Deng H, Luo M. Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-l-methionine. J Am Chem Soc. 2012 Apr 4;134(13):5909-15.
• Chen J, Levin LR, Buck J. Role of soluble adenylyl cyclase in the heart. Am J Physiol Heart Circ Physiol. 2012 Feb;302(3):H538-43.
• Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C. Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. J Mol Biol. 2012 Feb 17;416(2):271-86.
• Chau DM, Crump CJ, Villa JC, Scheinberg DA, Li YM. Familial Alzheimer disease Presenilin-1 mutations alter the active site conformation of y-secretase. J Biol Chem. 2012 May 18;287(21):17288-96. doi: 10.1074/jbc.M111.300483.
• Crump CJ, Am Ende CW, Eric Ballard T, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for y-secretase. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000.
• Marcinkiewicz K, Scotland KB , Boorjian SA, Nilsson EM, Persson JL, Abrahamsson PA, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP. The androgen receptor and stem cell pathways in prostate and bladder cancers (review). Int J Oncol. 2012 Jan;40(1):5-12. doi: 10.3892/ijo.2011.1212.
• Bath KG, Jing DQ, Dincheva I, Neeb CC, Pattwell SS, Chao MV, Lee FS, Ninan I. BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology. 2012 Apr;37(5):1297-304. doi: 10.1038/npp.2011.318.
• Dincheva I, Glatt CE, Lee FS. Impact of the BDNF Val66Met Polymorphism on Cognition: Implications for Behavioral Genetics. Neuroscientist. 2012 Oct;18(5):439-51

2011

• Mallikaratchy PR, Ruggiero A, Gardner JR, Kuryavyi V, Maguire WF, Heaney ML, McDevitt MR, Patel DJ, Scheinberg DA. A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia. Nucleic Acids Res. 2011 Mar;39(6):2458-69. doi: 10.1093/nar/gkq996. Epub 2010 Oct 28. PMID:21030439.

• Vorlová S, Rocco G, Lefave CV, Jodelka FM, Hess K, Hastings ML, Henke E, Cartegni L. Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation. Mol Cell. 2011 Sep 16;43(6):927-39. doi: 10.1016/j.molcel.2011.08.009.
• Lee YS, Tresguerres M, Hess K, Marmorstein LY, Levin LR, Buck J, Marmorstein AD. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. J Biol Chem. 2011 Dec 2;286(48):41353-8.
• Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, Kastenhuber ER, Taschereau R, Plaisier SB, Tran C, Heguy A, Wu H, Sander C, Phelps ME, Brennan C, Port E, Huse JT, Graeber TG, Mellinghoff IK. 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer Res. 2011 Aug 1;71(15):5164-74. doi: 10.1158/0008-5472.CAN-10-4633.
• Wee B, Charles N, Holland EC. Animal models to study cancer-initiating cells from glioblastoma. Front Biosci. 2011 Jun 1;17:2243-58.
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