Pharmacology
liaoblenis

Selected Publications

UPDATED: 6-6-2024

2024

2023

  • Epigenetic dysregulation from chromosomal transit in micronuclei, Albert S. Agustinus, Duaa Al-Rawi, Bhargavi Dameracharla, Ramya Raviram, Bailey S. C. L. Jones, Stephanie Stransky, Lorenzo Scipioni, Jens Luebeck, Melody Di Bona, Danguole Norkunaite, Robert M. Myers, Mercedes Duran, Seongmin Choi, Britta Weigelt, Shira Yomtoubian, Andrew McPherson, Eléonore Toufektchan, Kristina Keuper, Paul S. Mischel, Vivek Mittal, Sohrab P. Shah, John Maciejowski, Zuzana Storchova, Enrico Gratton, Peter Ly, Dan Landau, Mathieu F. Bakhoum, Richard P. Koche, Simone Sidoli, Vineet Bafna, Yael David & Samuel F. Bakhoum Show fewer authors.  Nature (2023)Cite this article

  • Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
    Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, Quast J, van den Heuvel J, Steegborn C, Levin LR, Buck J, Myers RW, Kargman S, Liverton N, Meinke PT, Huggins DJ.J Chem Inf Model. 2023 May 8;63(9):2828-2841. doi: 10.1021/acs.jcim.2c01577. Epub 2023 Apr 15.PMID: 37060320

  • BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A.Science. 2023 Jan 20;379(6629):eabj7412. doi: 10.1126/science.abj7412. Epub 2023 Jan 20.PMID: 36656933

2022

  • Antman-Passig, M., Wong, E., Frost, G. R., Cupo, C., Shah, J., Agustinus, A., Chen, Z., Mancinelli, C., Kamel, M., Li, T., Jonas, L. A., Li, Y. M., & Heller, D. A. (2022). Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-Beta. ACS Nano. https://doi.org/10.1021/acsnano.2c00054

  • Acosta, D. M., Mancinelli, C., Bracken, C., & Eliezer, D. (2022). Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. Journal of Biological Chemistry, 298(1), 101442. https://doi.org/10.1016/j.jbc.2021.101442 

  • Seaho Kim, CheukMan C Au, Mohd Azrin Bin Jamalruddin, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou (2022) AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer eLife 11:e73396 https://doi.org/10.7554/eLife.73396

2021

  • Gardner TJ, Lee JP, Bourne CM, Wijewarnasuriya D, Kinarivala N, Kurtz KG, Corless BC, Dacek MM, Chang AY, Mo G, Nguyen KM, Brentjens RJ, Tan DS, Scheinberg DA. Engineering CAR-T cells to activate small-molecule drugs in situ. Nat Chem Biol. 2021 Dec 30. doi: 10.1038/s41589-021-00932-1. Online ahead of print.PMID: 34969970

  • R Langenbacher, J Budhathoki-Uprety, PV Jena, D Roxbury, J Streit, M Zheng, DA Heller*. “Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes.” Nano Letters 21 (2021) 6441-6448. https://pubs.acs.org/doi/10.1021/acs.nanolett.1c01093

  • Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T. Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity Cancer Cell. 2021 Jul 12;39(7):973-988.e9. doi: 10.1016/j.ccell.2021.05.006. Epub 2021 Jun 10.PMID: 34115989

  • Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. CTLA-4 blockade drives loss of T<sub>reg</sub> stability in glycolysis-low tumours. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. PMID: 33588426.

  • Yang L, Han Y, Jaffré F, Nilsson-Payant BE, Bram Y, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Xiang J, Ho DD, tenOever BR, Schwartz RE, Evans T, Chen Z, Chen S. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 Apr 15. doi: 10.1161/CIRCRESAHA.121.319060. Epub ahead of print. PMID: 33853355.

2020

  • Chui, A.C.; Griswold, A.R.; Taabazuing, C.Y.; Orth, E.L.; Gai, K.; Rao, S.D.; Ball, D.P.;Hi Je. # “Activation of the CARD8 inflammasome requires a disordered region.” Cell Reports. 2020, 33, 108264.

  • Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. 2020 Sep 2. doi: 10.1038/s41586-020-2681-2. Online ahead of print. PMID: 32879487

2019

2018 (Updated 10/2019)

2017 (Updated 10/2017)

2016

2015

2014

2013

2012

2011

2010

  • Ibez G, McBean JL, Astudillo YM, Luo M. An enzyme-coupled ultrasensitive luminescence assay for protein methyltransferases. Anal Biochem. 2010 Jun 15;401(2):203-10.
  • French JB, Cen Y, Vrablik TL, Xu P, Allen E, Hanna-Rose W, Sauve AA. Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism.Biochemistry. 2010 Dec 14;49(49):10421-39.
  • Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind AB. Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J Biol Chem. 2010 Dec 10;285(50):38801-10.
  • Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW. Genetic dissection reveals unexpected influence of {beta} subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2010 Nov 17. [Epub ahead of print]
  • Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA. Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors. Cancer Res. 2010 Nov 15;70(22):9277-86.
  • Purtell K, Roepke TK, Abbott GW. Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol. 2010 Nov;42(11):1767-70.
  • Ruggiero A, Villa CH, Holland JP, Sprinkle SR, May C, Lewis JS, Scheinberg DA, McDevitt MR. Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes Int J Nanomedicine. 2010 Oct 5;5:783-802.
  • Kashyap V, Gudas LJ, Brenet F, Funk P, Viale A, Scandura JM. Epigenomic reorganization of the clustered hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem. 2010 Nov 18. [Epub ahead of print]
  • Tian Y, Crump CJ, Li YM. Dual Role of {alpha}-Secretase Cleavage in the Regulation of {gamma}-Secretase Activity for Amyloid Production. J Biol Chem. 2010;285(42):32549-56.
  • Seideman JH, Shum D, Djaballah H, Scheinberg DA. A high-throughput screen for alpha particle radiation protectants. Assay Drug Dev Technol. 2010 Oct;8(5):602-14
  • Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic {gamma}-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010 Nov 29. [Epub ahead of print]
  • Escobar-Alvarez S, Gardner J, Sheth A, Manfredi G, Yang G, Ouerfelli O, Heaney ML, Scheinberg DA. Inhibition of Human Peptide Deformylase Disrupts Mitochondrial Function. Mol Cell Biol. 2010Nov;30(21):5099-109.
  • Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling. Cancer Res. 2010 Sep 1;70(17):6804-14. [Epub 2010 Aug 10].
  • Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. (2010) Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells. Circulation. 2010 Aug 24;122(8):771-81.
  • Truman JP, Garc�a-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One. 2010 Aug 19;5(8):e12310.
  • Wang R, Wang G, Ricard MJ, Ferris B, Strulovici-Barel Y, Salit J, Hackett NR, Gudas LJ, Crystal RG. (2010) Smoking-induced Up-regulation of AKR1B10 Expression in the Airway Epithelium of Healthy Individuals. Chest. 2010 Dec;138(6):1402-10.
  • Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010 Sep;22(9):1300-7.
  • Xu G, Paige JS, Jaffrey SR. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat Biotechnol. 2010 Aug;28(8):868-73.
  • Harkcom WT, Abbott GW. Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther. 2010 Aug;8(8):1161-73. Review.
  • Kashyap V, Gudas LJ. Epigenetic regulatory mechanisms distinguish retinoic acid mediated transcriptional responses in stem cells and fibroblasts. J Biol Chem. 2010;285(19):14534-48.
  • Ruggiero A, Villa CH, Bander E, Rey DA, Bergkvist M, Batt CA, Manova-Todorova K, Deen WM, Scheinberg DA, McDevitt MR. Paradoxical glomerular filtration of carbon nanotubes Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12369-74.
  • Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia PLoS One. 2010 Jul 6;5(7):e11451.
  • Placanica L, Chien JW, Li YM. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 2010 Apr 6;49(13):2796-804
  • Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T, Shmelkov E, Kushner JS, Baljevic M, Dincheva I, Murphy AJ, Valenzuela DM, Gale NW, Yancopoulos GD, Ninan I, Lee FS, Rafii S. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med. 2010 May;16(5):598-602.
  • Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol. 2010 May;7(5):266-76.
  • Stancevic B, Kolesnick R. Ceramide-rich platforms in transmembrane signaling. FEBS Lett. 2010 May 3;584(9):1728-40.
  • Choi E, Abbott GW. A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor.FASEB J. 2010 May;24(5):1518-24.
  • Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production Nat Struct Mol Biol. 2010 Feb;17(2):151-8.
  • Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F, Toth M. The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7592-7.
  • Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK. The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6459-64
  • Deeb RS, Cheung C, Nuriel T, Lamon BD, Upmacis RK, Gross SS, Hajjar DP. Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress. J Am Chem Soc. 2010 Mar 24;132(11):3914-22.
  • Wyerbacher AR, Xu Q, Tamasdan C, Shin SJ, Inturrisi CE. N-Methyl-D-aspartate receptor (NMDAR) independent maintenance of inflammatory pain. Pain. 2010 Feb;148(2):237-46.
  • Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.Cell Stem Cell. 2010 Feb 5;6(2):141-52.
  • Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res. 2010 Feb 1;70(3):957-67.
  • Charles NA, Holland EC. TRRAP and the maintenance of stemness in gliomas. Cell Stem Cell. 2010 Jan 8;6(1):6-7.
  • Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7.
  • Kolesnick R, van den Brink M, Heller G, Rotolo JA. Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Jan 14;115(2):436.

2009

  • Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. (2009) Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33.
  • Choi E, Abbott GW. A shared mechanism for lipid- and {beta}-subunit-corrdinated stabilization of the activated K+ channel voltage sensor. (2009) FASEB J. 2009 Dec 29 [Epub ahead of print]
  • Shelton CC, Tian Y, Frattini MG, Li YM. A A miniaturized 1536-well format gamma-secretase assay. (2009) Assay Drug Dev Technol. 2009 Oct;7(5):461-70.
  • Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. (2009) Kcne2 deletion uncovers its critical role in thyroid hormone biosynthesis. Nature Medicine 2009 Oct;15(10):1186-94.
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. (2009) Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22;114(17):3693-706. .PMID: 196668.
  • Shelton C.C., Tian Y., Frattini M.G., Li Y.M. (2009) An exo-cell assay for examining real-time gamma-secretase activity and inhiobition. Mol Neurodegener Jun;2(4):22.
  • Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. (2009) Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4 and SOX2 pluripotency transcription factors with polycomb reoressive comlexes and stem cell micro-RNAs. Stem Cells Dev. 2009 Sep;18(7):1093-108.
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22;114(17):3693-706.
  • Charles N, Holland EC. Brain tumor treatment increases the number of cancer stem-like cells. Expert Rev Neurother. 2009 Oct;9(10):1447-9
  • Tang X.H., Su D., Albert M., Scognamiglio T., Gudas L.J. (2009) Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther. 2009 Jul;8(13):1214-25.
  • Broadbelt N.V., Chen J., Silver R.B., Poppas D.P. Felsen D. (2009) Pressure activates epidermal growth factor receptor (EGFR) leading to the induction of iNOS via NF{kappa}B and STAT3 in human proximal tubule cells (HKC-8). Am J Physiol Renal Physiol. 2009 Jul;297(1):F114-24.
  • Placanica L., Zhu L, Li Y.M. (2009) Gender- and - age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS ONE 4(4):e5088.
  • Oh J.E., Zupan B., Gross S., Toth M. (2009) Paradoxical Anxiogenic Response of Juvenile Mice to Fluoxetine. Neuropsychopharmacology. 2009 Sep;34(10):2197-207.
  • Scotland KB, Chen S, Sylvester R, Gudas LJ. Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation. Dev Dyn. 2009 Aug;238(8):1863-77.
  • Dao T, Korontsvit T, Zakhaleva V, Haro K, Packin J, Scheinberg DA. Identification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cells. PLoS One. 2009 Aug 25;4(8):e6730.
  • Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009 Jul 30;63(2):189-202.
  • Dorn D.C., Kou C.A., Png K.J., Moore M.A. (2009) The effect of cantharidins on leukimic stem cells. Int J Cancer May1;124(9):2186-99.
  • Sun Y., Zupan B., Raaka B.M., Toth M., Gershengorn M.C. (2009) TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Neuropsychopharmacology May;34(6):1601-8.
  • McCrossan Z.A., Roepke T.K., Lewis A., Panaghie G., Abbott G.W. (2009) Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol, Mar;228(1):1-14.
  • Yu Y.C., Bultje R.S., Wang X., Shi S.H. (2009) Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature Mar 26;458(7237):501-4.
  • Branski R.C., Barbieri S.S., Weksler B.S., Saltman B., Krishna P., Kraus D.H., Broadbelt N.V., Chen J., Poppas D.P., Felsen D. (2009) Effects of transforming growth factor-beta1 on human vocal fold fibroblasts. Ann Otol Rhinol Laryngol Mar;118(3):218-26.
  • Huse J.T., Brennan C., Hambardzumyan D., Wee B., Pena J., Rouhanifard S.H., Sohn-Lee C., Le Sage C., Agami R., Tuschl T., Holland E. (2009) The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes & Development, 23:1327-1337.
  • Yang G., Yin Y.I., Shelton C.C., Ouerfelli O., and Li Y.M. (2009) Strereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors. Bioorg Med Chem Lett, 19(3): 922-925.    
  • Placanica L., Tarassishin L., Yang G., Peethumnongsin E., Kim S.H., Zheng H., Sisodia S.S., and Li Y.M. (2009) Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2{gamma}-Secretase complexes. J Bio Chem;284(5):2967-2977.  
  • Meng R.D., Shelton C.C., Li Y.M., Qin L.X., Notterman D., Paty P.B., and Schwartz G.K. (2009) Gamma-secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res; 69:573-582.
  •  Xu X., Kanda V.A., Choi E., Panaghie G., Roepke T.K., Gaeta S.A., Christini D.J., Lerner D.J., Abbott G.W. (2009) Mink-dependent internnalization of the IKs potassium channel. Cardiovascular Res. Jun 1;82(3);430-8.
  • Zippin JH, Chadwick PA, Levin LR, Buck J, Magro CM. (2010) Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol. 2010 May;130(5):1279-87. PMID: 20130594
  • Escobar-Alvarez S., Goldgur Y., Yang G., Ouerfelli O., Li Y., Scheinberg D.A. (2009) Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol Apr 17;387(5):1211-28.
  • Acin-Perez R., Salazar E., Kamenetsky M, Buck J., Levin L.R., and Manfredi G. (2009) Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metabol Mar;9(3):265-76.
  • Rotolo J.A., Kolesnick R., and Fukc Z. (2009) Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys; 73(1):6-8.
  • Fernandez C.C., Gudas L.J. (2009) The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells. J Cell Biochem Feb 15;106(3):427-43.
  • Bogulavsky J.J., Gregus A.M., Kim P.T., Costa A.C., Rajadhyaksha A.M., Inturrisi C.E. (2009) Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development affects the development of morphine tolerance. J Pharmacol Exp Ther Feb;328(2):579-87.
  • Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. (2010) Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. PMID: 20018667.

2008

  • Gomez-Nunez M., Haro K.J., Dao T., Chau D., Won A., Escobar-Alvarez S., Zakhaleva V., Korontsvit T., Gin D.Y., Schienberg D.A. (2008) Non-natural and photo-reactive amino acids as biochemical probes of immune function. PLoS ONE 3(12);e3938.
  • Panaghie G., Purtell K, Tai K.K., Abbott G.W.(2008) Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J;95:2759-78.
  • Paige J.S., Xu G., Stancevic B., Jaffrey S.R. (2008) Nitrosothiol reactivity profiling identifies S-nitrosylated proteins with unexpected stability. Chem Biol; 15(12):1307-1316.
  • Xu Q., Garraway S.M., Weyerbacher A.R., Shin S.J., Inturrisi C.E. (2008) Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity. J Neurosci; 28(52):14087-96.
  • Villa C.H., McDevitt M.R., Escorcia F.E., Rey D.A., Bergkvist M., Batt C.A., Scheinberg D.A. (2008) Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes. Nano Lett Dec;8(12);4221-8.
  • Farrell J., Ramos L., Tresguerres M., Kamenetsky M., Levin L.R., and Buck J. (2008) Somatic 'Soluble' adenylyn cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'Knockout' mice. PLoS ONE; 3(9):e3251.
  • Ramos L.S., Zippin J.H., Kamentsky M., Buck J., Levin L.R. (2008) Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol Sep;132(3):329-38.
  • Xu J., Sylvester R., Tighe A.P., Chen S., Gudas L.J. (2008) Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wil-type cells. J Mol Biol, 377:28-46.
  • Guasparri, I., Bubman, D., and Cesarman, E. (2008) EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression. Blood, 111:3813-3820.
  • Nuriel, T., Deeb, R.S., Hajjar, D.P., and Gross, S.S. (2008) Protein 3-nitrotyrosine in complex biological samples: quantification by high-pressure liquid chromatography/electrochemical detection and emergence of proteomic approaches for unbiased identification of modification sites. Methods Enzymol, 441:1-17.
  • Cheng, H.T., Suzuki, M., Hegarty, D.M., Xu, Q., Weyerbacher, A.R., South, S.M., Ohata, M., and Inturrisi, C.E. (2008) Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn. Neuroscience Aug 26;155(3):948-58.
  • Tatapudy, S., Bruening, S., Gleason, G., and Toth, M. (2008) Validation and use of a computer-assisted counting procedure to quantify BrdU-labeled proliferating cells in the early postnatal mouse hippocampus. J Neurosci Methods Jul 30;172(2);173-7..
  • Abbott, G.W., Gordon, E., and Davison, J. (2008) Expanding roles of Aboriginal health workers in the primary care setting: seeking recognition. Contemp Nurse, 27:157-164.
  • Zupan B., and Toth M., (2008) Inactivation of the maternal fragile X gene results in sensitization of GABA receptor function in the offspring. J Pharmacol Exp ther. Dec;327(3):820-6.
  • Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res. 2008 Nov 15;68(22):9375-83.
  • Zupan, B. and Toth, M. (2008) Wild-Type Male Offspring of fmr-1(+/-) Mothers Exhibit Characteristics of the Fragile X Phenotype. Neuropsychopharmacology Oct;33(11):2667-75.
  • Gordon, E., Panaghie, G., Deng, L., Bee, K. J., Roepke, T. K., Krogh-Madsen, T., Christini, D. J., Ostrer, H., Basson, C. T., Chung, W., and Abbott, G. W. (2008) A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res, 77:98-106.
  • Su, D. and Gudas, L. J. (2008) Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. Biochem Pharmacol, 75:1129-1160.
  • Taldone T., Gozman A., Maharaj R., Chiosis G. (2008) Targeting Hsp90: smallmolecule inhibitors and their clinical development. Curr Opin Pharmacol Aug;8(4):370-4.
  • Halilovic E, Solit DB. Therapeutic strategies for inhibiting oncogenic BRAF signaling. Curr Opin Pharmacol. 2008 Aug;8(4):419-26.
  • Langton, S. and Gudas, L. J. (2008) CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid. Dev Biol, 315:331-354.
  • Rotolo, J. A., Maj, J. G., Feldman, R., Ren, D., Haimovitz-Friedman, A., Cordon-Cardo, C., Cheng, E. H., Kolesnick, R., and Fuks, Z. (2008) Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys, 70:804-815.
  • Platholi, J., Heerdt, P. M., Lim Tung, H. Y., and Hemmings, H. C., Jr. (2008) Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3gamma. J Neurochem. 105(5):2029-38.
  • Zhang, T. T., Platholi, J., Heerdt, P. M., Hemmings, H. C., Jr., and Tung, H. Y. (2008) Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metab Brain Dis, 23:95-104.
  • Su, D. and Gudas, L. J. (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol, 36:624-641.
  • Young J.J., Mehdi A., Stohl L.L., Levin L.R., Buck J., Wagner J.A., Stessin A. (2008) "Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells. J Neurosci Res Jan;86(1):188-24.

2007

  • Nolan, D. J., Ciarrocchi, A., Mellick, A. S., Jaggi, J. S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M. R., Scheinberg, D. A., Benezra, R., and Mittal, V. (2007) Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev, 21:1546-1558.
  • McDevitt, M. R., Chattopadhyay, D., Jaggi, J. S., Finn, R. D., Zanzonico, P. B., Villa, C., Rey, D., Mendenhall, J., Batt, C. A., Njardarson, J. T., and Scheinberg, D. A. (2007) PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE, 2:e907.
  • Gillespie, R. F. and Gudas, L. J. (2007) Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. J Biol Chem, 282:33421-33434.
  • Gillespie, R. F. and Gudas, L. J. (2007) Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. J Mol Biol, 372:298-316.
  • Bubman, D., Guasparri, I., and Cesarman, E. (2007) Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene, 26:4979-4986.
  • Choi, E. and Abbott, G. W. (2007) The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol, 72:499-501.
  • Antczak, C., Shum, D., Escobar, S., Bassit, B., Kim, E., Seshan, V. E., Wu, N., Yang, G., Ouerfelli, O., Li, Y. M., Scheinberg, D. A., and Djaballah, H. (2007) High-throughput identification of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen, 12:521-535.
  • Escorcia, F. E., McDevitt, M. R., Villa, C. H., and Scheinberg, D. A. (2007) Targeted nanomaterials for radiotherapy. Nanomed, 2:805-815.
  • Abbott, P., Gordon, E., and Davison, J. (2007) Expanding roles of Aboriginal health workers in the primary care setting: seeking recognition. Contemp Nurse, 26:66-73.
  • Garraway, S. M., Xu, Q., and Inturrisi, C. E. (2007) Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. J Pharmacol Exp Ther, 322:982-988.
  • Jaggi, J. S., Carrasquillo, J. A., Seshan, S. V., Zanzonico, P., Henke, E., Nagel, A., Schwartz, J., Beattie, B., Kappel, B. J., Chattopadhyay, D., Xiao, J., Sgouros, G., Larson, S. M., and Scheinberg, D. A. (2007) Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor.J Clin Invest, 117:2422-2430.
  • McDevitt, M. R., Chattopadhyay, D., Kappel, B. J., Jaggi, J. S., Schiffman, S. R., Antczak, C., Njardarson, J. T., Brentjens, R., and Scheinberg, D. A. (2007) Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med, 48: 1180-1189.
  • Singh Jaggi, J., Henke, E., Seshan, S. V., Kappel, B. J., Chattopadhyay, D., May, C., McDevitt, M. R., Nolan, D., Mittal, V., Benezra, R., and Scheinberg, D. A. (2007) Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PLoS ONE, 2:e267.
  • Sofou, S., Kappel, B. J., Jaggi, J. S., McDevitt, M. R., Scheinberg, D. A., and Sgouros, G. (2007) Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers. Bioconjug Chem, 18:2061-2067.
  • Angeles, A. R., Dorn, D. C., Kou, C. A., Moore, M. A., and Danishefsky, S. J. (2007) Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angew Chem Int Ed Engl, 46:1451-1454.
  • Lahiri, S., Lee, H., Mesicek, J., Fuks, Z., Haimovitz-Friedman, A., Kolesnick, R. N., and Futerman, A. H. (2007) Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett, 581:5289-5294.
  • Paige, J. S. and Jaffrey, S. R. (2007) Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions. Curr Top Med Chem, 7:97-114.
  • Panaghie, G. and Abbott, G. W. (2007) The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol, 129:121-133.
  • Vetrivel, K. S., Gong, P., Bowen, J. W., Cheng, H., Chen, Y., Carter, M., Nguyen, P. D., Placanica, L., Wieland, F. T., Li, Y. M., Kounnas, M. Z., and Thinakaran, G. (2007) Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener, 2:4.
  • Bullock, S. A., Platholi, J., Gjyrezi, A., Heerdt, P. M., Tung, H. Y., and Hemmings, H. C., Jr. (2007) Differential regulation of protein phosphatase-1(I) by neurabin. Biochem Biophys Res Commun, 358:140-144.
  • Derakhshan, B., Wille, P. C., and Gross, S. S. (2007) Unbiased identification of cysteine S-nitrosylation sites on proteins. Nat Protoc, 2:1685-1691.
  • Shang, S., Iwadare, H., Macks, D. E., Ambrosini, L. M., and Tan, D. S. (2007) A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Org Lett, 9:1895-1898.
  • Young, J.J.*, Mehdi, A.*, Stohl, L., Levin, L.R., Buck, J., Wagner, J.A., and Stessin A.M. (2007). 'Soluble' adenylyl cyclase-generated cyclic AMP promotes fast migration in PC12 cells. J. Neurosci. Res. 86:118-124.
  • Yang T., Chan N.Y., and Sauve A.A. (2007) Syntheses of nicotinamide ribosideand derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells. J Med Chem;50(26):6458-6461.
  • Broadbelt, N.V., Stahl P.J., Chen J., Mizrahi M., Lal A., Bozkurt A., Poppas D.P., Felsen D. (2007) Early upregulation of iNOS mRNA expression and increase in NO metabolites in pressurized renal epithelial cells. Am J Physiol Renal Physiol Dec;293(6):F1877-88.

2006

  • Kamenetsky, M., Middelhaufe, S. Bank, E.M., Levin, L.R., Buck, J., and Steegborn, C. (2006). Molecular details of cAMP generation in mammalian cells: A tale of two systems. J. Mol. Biol. 362:623-629.
  • Bruening S., Oh E., Hetzenauer A., Escobar-Alvarez S., Westphalen R.I., Hemmings H.C. Jr, Singewald N., Shippenberg T., and Toth M. (2006) The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. J Neurochem. 99(3):892-899.
  • Kushnir-Sukhov, N. M., Gilfillan, A. M., Coleman, J. W., Brown, J. M., Bruening, S., Toth, M., and Metcalfe, D. D. (2006) 5-hydroxytryptamine induces mast cell adhesion and migration. J Immunol, 177:6422-6432.
  • Chaloupka, J.A., Bullock, S.A., Iourgenko, V., Levin, L.R., and Buck, J. (2006). Autoinhibitory regulation of soluble adenylyl cyclase. Mol. Repro & Dev. 73:361-368.
  • Mogenson, E.G., Janbon, G., Chaloupka, J., Steegborn, C., Fu, M.S., Moyrand, F., Klengel, T., Pearson. D.S., Geeves, M.A., Buck. J., Levin, L.R.and Muhlschlegel, F.A. (2006). Cryptococcus senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryotic Cell 5:103-111.
  • Mahurter L., Garceau C., Marino J., Schmidhammer H., Toth G., Pasternak G.W. (2006) Separation of binding affinity and intrinsic activity of the potent mu opioid 14-methoxymetopon. J Pharmacol Exp Ther. 319(1):247-253.
  • Gordon E., Roepke T.K., and Abbott G.W. (2006). Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophysical Journal 90(4):1223-31.
  • Gordon E., Cohen J.L., Engel R., and Abbott G.W. (2006). 1,4-diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Molecular Pharmacology 69(3):718-726.
  • Jaggi, J. S., Seshan, S. V., McDevitt, M. R., Sgouros, G., Hyjek, E., and Scheinberg, D. A. (2006) Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. Int J Radiat Oncol Biol Phys, 64:1503-1512.
  • Gomez-Nunez, M., Pinilla-Ibarz, J., Dao, T., May, R. J., Pao, M., Jaggi, J. S., and Scheinberg, D. A. (2006) Peptide binding motif predictive algorithms correspond with experimental binding of leukemia vaccine candidate peptides to HLA-A*0201 molecules. Leuk Res, 30:1293-1298.
  • Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci. 9:1257-1264.
  • Stessin, A.M., Zippin, J.H., Kamenetsky M., Hess, K.C., Buck, J., and Levin, L.R. (2006). Soluble adenylyl cyclase mediates NGF-induced activation of RAP1. J. Biol. Chem. 281:17253-17258.
  • Pinilla-Ibarz, J., May, R. J., Korontsvit, T., Gomez, M., Kappel, B., Zakhaleva, V., Zhang, R. H., and Scheinberg, D. A. (2006) Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein. Leukemia, 20:2025-2033.
  • Kappel, B. J., Pinilla-Ibarz, J., Kochman, A. A., Eng, J. M., Hubbard, V. M., Leiner, I., Pamer, E. G., Heller, G., van den Brink, M. R., and Scheinberg, D. A. (2006) Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model. Blood, 107:2045-2051.
  • Antczak, C., Jaggi, J. S., LeFave, C. V., Curcio, M. J., McDevitt, M. R., and Scheinberg, D. A. (2006) Influence of the linker on the biodistribution and catabolism of actinium-225 self-immolative tumor-targeted isotope generators. Bioconjug Chem, 17:1551-1560.
  • Panaghie G.; Tai K.K.; Abbott G.W. (2006) Interaction of KCNE subunits with the KCNQ1 K+ channel pore. Journal of Physiology 570 (Pt 3):455-67.
  • Panaghie G.; Abbott G.W. (2006) The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Current Pharmaceutical Design 12(18):2285-2302.
  • Yun, S.W., Platholi, J., Flaherty, M.S., Fu, W., Kottmann, A.H., and Toth, M. (2006) Fmrp is required for the establishment of the startle response during the critical period of auditory development. Brain Res. 1110(1):159-65.
  • Moilanen, S. B.; Potuzak, J. S.; Tan, D. S. (2006) Stereocontrolled synthesis of spiroketals via a Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. J Am Chem Soc. 128:1792-1793.
  • Sheren-Manoff, M., Shin, S. J., Su, D., Bok, D., Rando, R. R., and Gudas, L. J. (2006) Reduced lecithin:retinol acyltransferase expression in human breast cancer. Int J Oncol, 29:1193-1199.

2005

  • Fan W, Bubman D, Chadburn A, Harrington WJ Jr, Cesarman E, Knowles DM. (2005) Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol. 79(2):1244-51.
  • Klengel, T.*, Liang, W-J.*, Chaloupka, J.A.*, Ruoff, C.,Schroppel, K., Naglik, J.R., Eckert, S.E., Gweiss, E., Haynes, K., Tuitte, M.F., Levin, L.R., Buck, J., and Muhlschlegel, F.A. (2005). Fungal adenylyl cyclase integrates CO2 sensing with CAMP aignalling and virulence. Curr. Biol. 15:2021-2026. (*contributed to equally).
  • Dao, T., Gomez-Nunez, M., Antczak, C., Kappel, B., Jaggi, J. S., Korontsvit, T., Zakhaleva, V., and Scheinberg, D. A. (2005) Natural killer cells license dendritic cell cross-presentation of B lymphoma cell--associated antigens. Clin Cancer Res, 11:8763-8772.
  • Jaggi JS, Seshan SV, McDevitt MR, Laperle K, Sgouros G, Scheinberg DA. (2005) Renal Tubulointerstitial Changes after Internal Irradiation with {alpha}-Particle-Emitting Actinium Daughters. J Am Soc Nephrol. 16(9):2677-2689.
  • Jaggi JS, Kappel BJ, McDevitt MR, Sgouros G, Flombaum CD, Cabassa C and Scheinberg DA. (2005) Efforts to Control the Errant Products of a Targeted In vivo Generator. Cancer Research 65(11):4888-95.
  • Han H, Stessin A, Roberts J, Hess K, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C. (2005) Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med. 202(3):353-61.
  • Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS, Levin LR, Williams CJ, Buck J, Moss SB. (2005) The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 9(2):249-59.
  • Wu KY, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR. (2005) Local translation of RhoA regulates growth cone collapse. Nature. 436(7053):1020-4.
  • Potuzak, J. S.; Moilanen, S. B.; Tan, D. S. (2005) Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. J Am Chem Soc. 127:13796-13797.
  • Rotolo, J.A., Zhang, J., Donepudi, M., Lee, H., Fuks, Z., Kolesnick, R. (2005) Caspase-dependent and-independent activation of acid sphingomyelinase signaling. J Biol Chem. 280(28):26425-26434.
  • Shang, S. and Tan, D. S. (2005) Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Curr Opin Chem Biol, 9:248-258.
  • Touma, S. E., Goldberg, J. S., Moench, P., Guo, X., Tickoo, S. K., Gudas, L. J., and Nanus, D. M. (2005) Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Cancer Res, 11:3558-3566.
  • Kortmansky, J., Shah, M. A., Kaubisch, A., Weyerbacher, A., Yi, S., Tong, W., Sowers, R., Gonen, M., O'Reilly, E., Kemeny, N., Ilson, D. I., Saltz, L. B., Maki, R. G., Kelsen, D. P., and Schwartz, G. K. (2005) Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors. J Clin Oncol, 23:1875-1884.
  • Shah, M. A., Kortmansky, J., Motwani, M., Drobnjak, M., Gonen, M., Yi, S., Weyerbacher, A., Cordon-Cardo, C., Lefkowitz, R., Brenner, B., O'Reilly, E., Saltz, L., Tong, W., Kelsen, D. P., and Schwartz, G. K. (2005) A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. Clin Cancer Res, 11:3836-3845.

2004

  • Zippin JH, Farrell J, Huron DR, Kamenetsky M, Hess KC, Fischman DA, Levin LR, Buck J. (2004) Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol. 164(4):527-34.
  • Potuzak, J. S., Tan, D. S. (2004) Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki-Miyaura cross coupling approach. Tetrahedron Lett. 45:1797-1801.
  • Potuzak, J. S., Moilanen, S. B.; Tan, D. S. (2004) Discovery and applications of small molecule probes for studying biological processes. Biotechnol. Genet. Eng. Rev. 21:11-78.

2003

  • Bubman D, Cesarman E. (2003) Pathogenesis of Kaposi's sarcoma. Hematol Oncol Clin North Am 17:717-45.
  • Anantharam A., Lewis A., Panaghie G., Gordon E., McCrossan Z.A., Lerner D.J., and Abbott G.W. (2003) RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem 278:11739-45.
  • Huron DR, Gorre ME, Kraker AJ, Sawyers CL, Rosen N, & Moasser, MM. (2003) A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants. Clin Cancer Res 9:1267-73.
  • Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR. (2003) Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem 278:15922-6.
  • Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J. (2003) Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J 17:82-4.
  • McCrossan Z.A.; Lewis A.; Panaghie G.; Jordan P.N.; Christini D.J.; Lerner D.J.; Abbott GW. (2003) MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 23(22):8077-91.

2002

  • Birk AV, Bubman D, Broekman MJ, Robertson HD, Drosopoulos JH, Marcus AJ, Szeto HH. (2002) Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology. J Lab Clin Med 139:116-24.
Directory News
Apply to a PhD Program Postdoctoral Positions

Weill Cornell Medicine Pharmacology 1300 York Avenue,
Room E-409 New York, NY 10021 Phone: (212) 746-6250 Fax: (212) 746-8835