Selected Recent Publications by Our Postdoctoral Fellows

Diani-Moore S, Shoots J, Singh R , Zuk JB, Rifkind AB . NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268. doi: 10.1038/s41598-017-02332-9. PMID:28536482

Marino A, Sakamoto T, Robador PA, Tomita K, Levi R .S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2. J Pharmacol Exp Ther. 2017 Aug;362(2):230-242. doi: 10.1124/jpet.117.241976. Epub 2017 May 12. PMID:28500264

Mauer J , Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS , Elemento O, Debart F, Kiledjian M, Jaffrey SR . Reversible methylation of m6Am in the 5' cap controls mRNA stability. Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21. PMID:28002401

Jaffrey SR, Kharas MG . Emerging links between m6A and misregulated mRNA methylation in cancer. Genome Med. 2017 Jan 12;9(1):2. doi: 10.1186/s13073-016-0395-8. PMID: 28081722

Olarerin-George AO, Jaffrey SR. MetaPlotR: a Perl/R pipeline for plotting metagenes of nucleotide modifications and other transcriptomic sites. Bioinformatics. 2017 May 15;33(10):1563-1564. doi: 10.1093/bioinformatics/btx002. PMID:28158328

Witkin LR, Zylberger D, Mehta N, Hindenlang M , Johnson C, Kean J, Horn SD, Inturrisi CE. Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain. J Pain. 2017 May;18(5):583-596. doi: 10.1016/j.jpain.2016.12.018. Epub 2017 Jan 12. PMID:28088507

Grozhik AV, Linder B, Olarerin-George AO, Jaffrey SR. Mapping m6A at Individual-Nucleotide Resolution Using Crosslinking and Immunoprecipitation (miCLIP). Methods Mol Biol. 2017;1562:55-78. doi: 10.1007/978-1-4939-6807-7_5.PMID:28349454

Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. The m6A pathway facilitates sex determination in Drosophila. Nat Commun. 2017 Jul 4;8:15737. doi: 10.1038/ncomms15737.PMID:28675155

Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD. Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors . J Ocul Pharmacol Ther. 2017 Jul 7. doi: 10.1089/jop.2017.0027. [Epub ahead of print]PMID:28686538

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16. PMID:26404765.

Meyer KD, Jaffrey SR. Expanding the diversity of DNA base modifications with N (6)-methyldeoxyadenosine. Genome Biol. 2016 Jan 13;17(1):5. doi: 10.1186/s13059-016-0874-7. PMID:26762117.

Arunachalam G, Lakshmanan AP, Samuel SM, Triggle CR, Ding H. Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin. J Pharmacol Exp Ther. 2016 Feb;356(2):314-23. doi: 10.1124/jpet.115.226894. Epub 2015 Nov 18. PMID:26582729.

Kim JY, Jaffrey SR. Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis. J Cell Biol. 2016 Mar 28;212(7):751-3. doi: 10.1083/jcb.201603028. PMID:27022088.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C. Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site. J Biol Chem. 2016 Mar 9. pii: jbc.M115.708255. [Epub ahead of print] PMID:26961873.